Echo MRI 3-in-1

描述（由申请人提供）：Echo MRI-100（tm）三合一肥胖是一个对人类健康影响越来越大的问题，目前美国超过60%的人口明显肥胖或超重。尽管这个问题很普遍，但几乎没有有效的治疗方法。小鼠模型为理解人类肥胖发展的重要途径提供了有价值的见解。这包括了解分子途径和饮食引起的肥胖的影响。分析小鼠模型需要技术能力来评估身体成分，特别是肥胖。BIDMC内分泌科肥胖研究小组目前使用的技术有很大的局限性。获得所要求的EchoMRI三合一将绕过这一限制，提高进行研究的能力，并减少所需队列的规模。此外，该设备将提供迄今为止无法获得的评估组织样本组成的能力，无论是来自啮齿动物还是来自人类活检样本。由于该设备的容量，除了BIDMC内分泌学院及其合作者预计的大量使用外，该服务还可以提供给BIDMC其他研究人员。

DESCRIPTION (provided by applicant): Echo MRI-100(tm) 3-in-1 Obesity is a problem with increasing impact on human health and at present more than 60% of the population in the U.S. is either frankly obese or overweight. Despite the prevalence of this problem there are few effective treatments. Mouse models have provided valuable insights into understanding pathways important in the development of human obesity. This includes understanding both molecular pathways and the effects of dietary induced obesity. Analysis of mouse models requires technical capacity to evaluate body composition, particularly adiposity. The technology currently available to the group of obesity researchers at the BIDMC division of Endocrinology has significant limitations. Acquisition of the requested EchoMRI 3-in-1 will bypass this limitation and enhance ability to perform studies and also decrease the size of cohorts required. In addition this equipment will provide a heretofore unavailable capacity to evaluate composition of tissue samples, either from rodents or from human biopsy samples. Because of the capacity of the equipment, in addition to projected significant use by BIDMC Endocrine faculty and their collaborators the service can be offered to other BIDMC investigators.