CLINICAL TRIAL: EXENATIDE AND BODY WEIGHT IN OBESE NON-DIABETIC WOMEN

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究将探讨exenglycine对体重，能量消耗，饱腹感，睡眠和代谢参数的中度肥胖妇女正常葡萄糖稳态或受损的葡萄糖稳态，但不是坦率的糖尿病。这是一项随机、双盲、交叉研究，受试者将接受艾塞那肽或安慰剂治疗16周，治疗期之间有2周的洗脱期。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine the effect of exenatide on weight, energy expenditure, satiety, sleep and metabolic parameters in moderately obese women with normal glucose homeostasis or with impaired glucose homeostasis but not frank diabetes mellitus. This is a randomized, double blind, crossover study in which subjects will receive exenatide or placebo for 16 weeks with a 2-week washout period between treatment periods.