CORE--PHYSIOLOGY

核心--生理学

• 批准号: 7392814
• 负责人: ELEFTHERIA MARATOS-FLIER
• 金额: $ 12.45万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392814
• 关键词: Affect; Animals; Area; Awareness; Body Composition; Boston; Carbon Dioxide; Cities; Complex; DEXA; Data; Data Analyses; Desire for food; Endocrine; Energy Metabolism; Evaluation; Experimental Designs; Food; Funding; Graph; Heating; Homeostasis; Human; Instruction; Intake; Laboratory Animals; Lead; Life; Measures; Metabolic; Monitor; Mus; Neuropeptides; Obese Mice; Obesity; Oxygen Consumption; Peptides; Peripheral; Physiology; Production; Regulation; Research Personnel; Rodent; Rodent Model; Rough endoplasmic reticulum; Running; Services; System; Technology; Time; Water; design; drinking; feeding; insight; instrument; instrumentation; interest; mouse model; research study; respiratory; tool

Evaluation of energy expenditure has become an indispensable tool for studies involving lean and obese mice. Systems capable of such evaluation are commercially available and can monitor activity, oxygen consumption, CO2 production, feeding and drinking. From this data respiratory quotient, RER and heat produced can be calculated. However the systems are expensive and sophisticated. The Endocrine Division at BIDMC has a sixteen animal monitoring system purchased by outside funds. To make the technology available to PPG investigators, monitoring is offered as a core service. Following monitoring data is provided to the requesting investigator as Excel spreadsheets and graphs plotting the variable of interest in real time. The core assists in experimental design and data analysis. An additional service of the core is assistance with DEXA monitoring for PPG projects.

能量消耗的评估已成为研究涉及瘦和肥胖小鼠的不可或缺的工具。能够进行这种评估的系统是市售的，并且可以监测 活动、耗氧量、CO2产生、进食和饮水。从这个数据呼吸 可以计算出商数、RER和产热。然而，这些系统是昂贵的， 很老练BIDMC的内分泌部门有一个由外部资金购买的16个动物监测系统。为了使PPG研究人员能够使用该技术，将监测作为核心服务提供。将以下监测数据以Excel电子表格和真实的实时绘制关注变量的图表的形式提供给请求研究者。核心协助实验设计和数据分析。核心的另一项服务是协助DEXA监测PPG项目。