POTENTIAL REGULATION OF FGF-21 BY FASTING AND DIET-INDUCED KETOSIS

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will examine the potential changes in the blood levels of a recently discovered metabolic regulator called fibroblast growth factor 21 (FGF-21) in response to changes in diet in healthy adults. Administration of FGF-21 has been shown to improve circulating glucose and lipid levels in mouse and monkey models of diabetes. In addition, exposure to FGF-21 improves the function of the insulin secreting cells of the pancreas in vitro. It is possible that FGF-21 plays an important role in physiological regulation of metabolism in humans. However, the way in which circulating levels of FGF-21 change is not known. The hypothesis is that in healthy adults FGF-21 levels will respond to changes in diet, particularly fasting and diet-induced ketosis.