600 MHz NMR Spectrometer Console

描述(由申请人提供)：美国国立卫生研究院资助的巴尔的摩马里兰大学的首席研究人员需要一台最先进的600 MHz核磁共振光谱仪控制台来开展他们由美国国立卫生研究院资助的核磁共振相关研究。这种设备对于(I)成为最先进的设备，(Ii)充分保护我们的低温探头和(Iii)减少由于我们现有600 MHz仪器的高故障率而导致的核磁共振停机时间是必要的。UMB核磁共振中心的用户包括医学院、药学院、Greenebaum癌症中心、马里兰大学生物技术中心的教职员工，以及来自其他大学和私营公司的用户。NIH正在资助的依赖于600 MHz核磁共振光谱仪的项目包括：1.David J.Weber博士，S100蛋白质的结构/功能和药物设计；2.Lindsay Black博士，噬菌体IPI蛋白质的结构/功能研究；3.Alex Drohat博士，通过核磁共振光谱学研究人类TDG催化核心的结构；4.A-Lien Lu-Chang博士，DNA错配修复蛋白质的结构和机制研究，5.Frank MarGolis博士，OMP与Bex蛋白质结合的结构/功能研究；6.玛丽·麦肯纳博士，单羧酸和氨基酸在大脑中的新陈代谢和运输；7.詹姆斯·纳塔罗博士，弥散素的结构/功能研究；8.克里斯汀·瓦尼博士，Mts1的结构和功能(S100A4)。此外，在本申请中还简要介绍了其他四个项目，这些项目也是继续使用600 MHz核磁共振光谱仪的基本需要。 相关性：由美国国立卫生研究院资助的巴尔的摩马里兰大学首席研究员正在研究的核磁共振相关项目解决了许多重要的公共卫生问题，包括癌症、艾滋病毒/艾滋病、老龄化、心脏病和药物设计的几个方面。

DESCRIPTION (provided by applicant): NIH-funded principal investigators at the University of Maryland, Baltimore have a scientific need for a state-of-the-art 600 MHz NMR spectrometer console to carry out their NIH funded NMR-related research. This equipment is necessary to (i) become state-of-the art, (ii) to adequately protect our cryogenic probe and (iii) to reduce the amount of NMR down-time resulting from the high failure rate of our existing 600 MHz instrumentation. The users of the UMB NMR center include faculty members from the School of Medicine, the School of Pharmacy, the Greenebaum Cancer Center, the University of Maryland Biotechnology center, and users from other universities and private companies. The ongoing NIH-funded projects that are dependent upon the 600 MHz NMR spectrometer include: 1. Dr. David J. Weber (PI), Structure/function and drug design for S100 proteins; 2. Dr. Lindsay Black, Structure/function studies of the phage IPI protein; 3. Dr. Alex Drohat, The structure of the human TDG catalytic core by NMR spectroscopy; 4. Dr. A-Lien Lu-Chang, Structural and Mechanistic Studies of DNA Mismatch Repair Proteins, 5. Dr. Frank Margolis, Structure/function studies of OMP bound to the Bex proteins; 6. Dr. Mary McKenna, Monocarboxylic acids and amino acids in metabolism and trafficking in the brain; 7. Dr. James Nataro, Structure/Function studies of Dispersin; 8. Dr. Kristen Varney, Structure and Function of Mts1 (S100A4). In addition, four other projects are briefly described in this application, which also have an essential need for continued use of the 600 MHz NMR spectrometer. Relevance: The ongoing NMR-related projects under study by NIH-funded principal investigators at the University of Maryland, Baltimore address many important public health concerns including cancer, HIV/AIDS, aging, heart disease, and several aspects of drug design.