600 MHz NMR Spectrometer Console

600 MHz 核磁共振波谱仪控制台

• 批准号: 7212707
• 负责人: David Joseph Weber
• 金额: $ 36.24万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7212707
• 关键词: AIDS/HIV problem; Acids; Address; Aging; Amino Acids; Arts; Bacteriophages; Baltimore; Binding; Biotechnology; Brain; Cancer Center; Catalytic Domain; DNA; Drug Design; Equipment; Faculty; Failure; Funding; Heart Diseases; Human; Malignant Neoplasms; Maryland; Metabolism; Mismatch Repair; NGFRAP1 gene; NMR Spectroscopy; Pharmacy Schools; Principal Investigator; Proteins; Public Health; Rate; Research; S100 Proteins; Structure; Time; United States National Institutes of Health; Universities; cryogenics; instrumentation; medical schools; member; trafficking

DESCRIPTION (provided by applicant): NIH-funded principal investigators at the University of Maryland, Baltimore have a scientific need for a state-of-the-art 600 MHz NMR spectrometer console to carry out their NIH funded NMR-related research. This equipment is necessary to (i) become state-of-the art, (ii) to adequately protect our cryogenic probe and (iii) to reduce the amount of NMR down-time resulting from the high failure rate of our existing 600 MHz instrumentation. The users of the UMB NMR center include faculty members from the School of Medicine, the School of Pharmacy, the Greenebaum Cancer Center, the University of Maryland Biotechnology center, and users from other universities and private companies. The ongoing NIH-funded projects that are dependent upon the 600 MHz NMR spectrometer include: 1. Dr. David J. Weber (PI), Structure/function and drug design for S100 proteins; 2. Dr. Lindsay Black, Structure/function studies of the phage IPI protein; 3. Dr. Alex Drohat, The structure of the human TDG catalytic core by NMR spectroscopy; 4. Dr. A-Lien Lu-Chang, Structural and Mechanistic Studies of DNA Mismatch Repair Proteins, 5. Dr. Frank Margolis, Structure/function studies of OMP bound to the Bex proteins; 6. Dr. Mary McKenna, Monocarboxylic acids and amino acids in metabolism and trafficking in the brain; 7. Dr. James Nataro, Structure/Function studies of Dispersin; 8. Dr. Kristen Varney, Structure and Function of Mts1 (S100A4). In addition, four other projects are briefly described in this application, which also have an essential need for continued use of the 600 MHz NMR spectrometer. Relevance: The ongoing NMR-related projects under study by NIH-funded principal investigators at the University of Maryland, Baltimore address many important public health concerns including cancer, HIV/AIDS, aging, heart disease, and several aspects of drug design.

描述（由申请人提供）：位于巴尔的摩的马里兰州大学的NIH资助的主要研究人员需要一台最先进的600 MHz NMR光谱仪控制台，以开展NIH资助的NMR相关研究。该设备是必要的，以（i）成为最先进的，（ii）充分保护我们的低温探头和（iii）减少我们现有的600 MHz仪器的高故障率造成的NMR停机时间。UMB NMR中心的用户包括来自医学院、药学院、Greenebaum癌症中心、马里兰州大学生物技术中心的教职员工，以及来自其他大学和私营公司的用户。正在进行的NIH资助的依赖于600 MHz NMR光谱仪的项目包括：1。大卫J韦伯博士（PI），结构/功能和药物设计S100蛋白; 2。林赛布莱克博士，噬菌体IPI蛋白的结构/功能研究; 3. Alex Drohat博士，通过NMR光谱分析人类TDG催化核心的结构; 4.连禄章博士，DNA错配修复蛋白质之结构与机制研究，5。Frank Margolis博士，与Bex蛋白结合的OMP的结构/功能研究; 6.玛丽麦肯纳，单羧酸和氨基酸在大脑中的代谢和贩运; 7。James Nataro博士，分散素的结构/功能研究; 8. Kristen Varney博士，Mts 1（S100 A4）的结构和功能。此外，在本申请中还简要介绍了其他四个项目，这些项目也对继续使用600 MHz NMR光谱仪有基本需求。 相关性：由美国国立卫生研究院资助的马里兰州大学（巴尔的摩）的主要研究人员正在进行的NMR相关项目涉及许多重要的公共卫生问题，包括癌症、艾滋病毒/艾滋病、衰老、心脏病和药物设计的几个方面。