Modified Elliptical Centric View Orders for Improved Real-Time MRA

描述（由申请人提供）：这项工作的广泛、长期目标是开发用于MR数据采集和相应实时信号处理技术的新颖、省时的方法，以形成以高空间分辨率描绘心血管系统的MR图像。由于心血管疾病的高发病率，这一点很重要。具体的研究目标是：1。改进的椭圆中心（EC）采集技术。EC视图顺序将与投影重建（PR）k空间采样相结合，以利用这两种方法的内在优势。将开发EC-PR技术的变体，以提供：（i）使用2D零差（HD）重建在给定时间内提高分辨率;（ii）帧速率高达2 Hz的时间分辨研究;（iii）与SENSE等并行成像方法兼容，扫描时间减少4倍;以及（iv）与SENSE和HD重建的组合的兼容性，用于针对给定分辨率的6倍扫描时间减少。新方法将应用于对比增强和非对比增强MRA研究。2.实时大剂量检测和跟踪。将开发一种方法，当造影剂团在扩展视野内移动通过脉管系统时，以完全自动化的方式真实的实时检测和跟踪造影剂团的传输。该信息将允许生成患者特定的团注速度曲线，其可以引导MR血管造影脉冲序列和控制扫描床速度，并在患者特定的基础上优化空间分辨率。3.全面的神经血管检查将整合目标1和2的新采集和实时计算技术，以在单次注射造影剂后提供主动脉弓和大血管、颈动脉分叉、颅内动脉和大脑引流静脉的全面血管造影照片。检查期间的适度扫描床运动将允许扩展FOV的成像。

DESCRIPTION (provided by applicant): The broad, long-term objective of this work is to develop novel, time-efficient methods for MR data acquisition and corresponding real-time signal processing techniques to allow formation of MR images which portray the cardiovascular system with high spatial resolution. This is significant due to the high incidence of cardiovascular disease. Specific aims to be studied in this work are: 1. Modified Elliptical Centric (EC) Acquisition Techniques. The EC view order will be combined with projection reconstruction (PR) k-space sampling to exploit the intrinsic advantages of both approaches. Variants of the EC-PR technique will be developed to provide: (i) improved resolution for given time using 2D homodyne (HD) reconstruction; (ii) time-resolved studies with frame rates as high as 2 Hz; (iii) compatibility with parallel imaging methods such as SENSE for 4-fold reduction in scan time; and (iv) compatibility with a combination of SENSE and HD reconstruction for 6-fold scan time reduction for given resolution. The new methods will be applied to contrast-enhanced as well as non-contrast-enhanced MRA studies. 2. Real-Time Bolus Detection and Tracking. Means will be developed to detect and track contrast bolus transit in real time in a totally automated way as it moves through the vasculature over an extended field of view. This information will allow the generation of patient-specific bolus velocity profiles which can guide the MR angiographic pulse sequence and control table velocity and optimize spatial resolution on a patient- specific basis. 3. The Comprehensive Neurovascular Examination. The new acquisition and real-time computation techniques of Aims 1 and 2 will be integrated to provide a comprehensive angiogram of the aortic arch and great vessels, the carotid bifurcations, the intracranial arteries, and the draining veins of the brain following a single injection of contrast. Modest table motion during the exam will permit imaging of the extended FOV.