Multimodal Imaging of the Sensory Gating Deficit in Chronic Cocaine Abusers

慢性可卡因滥用者感觉门控缺陷的多模态成像

基本信息

  • 批准号:
    7386988
  • 负责人:
  • 金额:
    $ 25.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-08-06 至 2009-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Cocaine dependence is a debilitating disease affecting millions of Americans and current treatment regimens are ineffective on nearly 90% of patients. Deficits in higher-order attention and memory processes (i.e., executive dysfunction, reduced working memory capacity and difficulties with attentional switching) are common amongst this group and likely contribute to relapse. However, even more basic deficits, including the failure to inhibit repeated sensory stimuli (i.e., sensory gating), are present. These gating deficits may be more severe in abusers with co-morbid psychiatric profiles such as a proneness to experience paranoia or users with more basic attentional disorders. Both of these sub-groups are associated with increased drug dependence and likelihood of relapse. A paradigm that is capable of identifying these sub-groups of users with associated co-morbidity issues would increase our knowledge on the neurobiology of addiction and could be used as a bio-marker for determining the efficacy of alternative treatment regimens, both of which are directly relevant to NIDA's overall mission statement. Therefore, we propose to use multimodal neuroimaging, including functional magnetic resonance imaging (FMRI), electroencephalography (EEG) and magnetoencephalography (MEG), and novel data fusion techniques to investigate basic inhibitory processes (i.e., sensory gating) in 12 healthy normal volunteers and 24 chronic cocaine abusers. Neuropsychological and psychological data will also be collected and correlated with performance on the gating task, with emphasis on clinical measures of attentional dysfunction and cocaine induced paranoia. The proposed task will be a variant of the traditional gating paradigm as participants will be exposed to pairs of identical tones and non-identical tones in addition to clicks. MEG and EEG data will be collected simultaneously, and FMRI data will be collected within 24 hours of the electrophysiological data. The specific aims of this project are 1) a more comprehensive understanding of the neurobiology of addiction by characterizing the neural networks (mesocorticolimbic pathway) underlying inhibitory processes to repeated and novel stimuli in chronic cocaine abusers, 2) to determine if basic failures in inhibition are indicative of faster relapse rates, and 3) to determine if basic inhibitory deficits are related to clinical characteristics (i.e., cocaine induced paranoia and attentional deficits) that are more prominent in certain sub-populations of abusers who might carry dual-diagnoses. This proposal is innovative and unique because it is one of the first attempts to utilize several different imaging modalities (FMRI/MEG/EEG) to investigate the neurobiology of addiction in a group where failures in inhibition have been shown to contribute to likelihood of relapse. Moreover, the use of multimodal neuroimaging and subsequent novel data fusion techniques will resolve a long-standing question in the gating literature, namely "where" and "when" the gating deficit occurs. Our long-term goal (planned R01 submission) is to evaluate the multi-modal imaging data as a predictor of treatment success, and to use task performance to identify a sub-group of patients where alternative treatment interventions should be considered. The minimal cognitive demands of this task also make it ideal for studying cocaine dependence in animals so that novel models of addiction can be developed and pharmacologically tested. Cocaine abuse continues to be a major health problem in the United States with approximately 1.8 million current users. Chronic cocaine abuse and dependence are associated with major medical, neurological, neuropsychiatric, social and interpersonal complications for the individual, their support network and society at whole. This grant will utilize neuroimaging techniques to increase our understanding of the neurobiology of addiction and to determine whether these techniques may be a more sensitive measure and predictor of relapse amongst certain sub-groups of cocaine users.
描述(由申请人提供):可卡因依赖是一种使人衰弱的疾病,影响数百万美国人,目前的治疗方案对近90%的患者无效。高阶注意力和记忆过程的缺陷(即,执行功能障碍、工作记忆能力下降和注意力转换困难)在这一群体中很常见,并可能导致复发。然而,甚至更基本的缺陷,包括未能抑制重复的感觉刺激(即,感觉门控)存在。这些门控缺陷可能会更严重的滥用者与共病的精神概况,如倾向于经历偏执狂或用户与更多的基本注意力障碍。这两个亚组都与药物依赖性增加和复发的可能性有关。一个范例,是能够识别这些亚组的用户与相关的并发症的问题,将增加我们的知识成瘾的神经生物学,并可以作为一个生物标志物,用于确定替代治疗方案的疗效,这两者都是直接相关的NIDA的整体使命声明。因此,我们建议使用多模态神经成像,包括功能磁共振成像(FMRI),脑电图(EEG)和脑磁图(MEG),以及新的数据融合技术来研究基本的抑制过程(即,感觉门控)。还将收集神经心理学和心理学数据,并将其与门控任务的表现相关联,重点是注意力功能障碍和可卡因诱导的偏执狂的临床测量。拟议的任务将是一个传统的门控范式的变体,因为参与者将接触到对相同的音调和不相同的音调,除了点击。MEG和EEG数据将同时采集,FMRI数据将在电生理数据采集后24小时内采集。这个项目的具体目标是:1)通过描述神经网络,更全面地了解成瘾的神经生物学(中皮质边缘通路)对慢性可卡因滥用者中重复和新刺激的潜在抑制过程,2)确定抑制中的基本失败是否指示更快的复发率,和3)确定基本抑制缺陷是否与临床特征相关(即,可卡因引起的妄想症和注意力缺陷),这在某些可能患有双重诊断的滥用者亚群中更为突出。这项建议是创新和独特的,因为它是第一次尝试利用几种不同的成像方式(功能磁共振成像/脑磁图/脑电图),以调查成瘾的神经生物学在一组抑制失败已被证明有助于复发的可能性。此外,使用多模态神经成像和随后的新的数据融合技术将解决一个长期存在的问题,在门控文献,即“在哪里”和“何时”门控赤字发生。我们的长期目标(计划的R 01提交)是评价多模态成像数据作为治疗成功的预测因子,并使用任务表现来识别应考虑替代治疗干预的患者亚组。这项任务的最低认知要求也使其成为研究动物可卡因依赖性的理想方法,以便开发和验证新的成瘾模型。可卡因滥用仍然是美国的一个主要健康问题,目前约有180万人使用可卡因。慢性可卡因滥用和依赖与个人、其支持网络和整个社会的重大医疗、神经、神经精神、社会和人际并发症有关。该资助将利用神经成像技术来增加我们对成瘾神经生物学的了解,并确定这些技术是否可能是某些可卡因使用者亚组复发的更敏感的衡量标准和预测指标。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biology, Culture and Environment: Methodological and Epistemological Principles for an Integrative Social Theory.
生物学、文化和环境:综合社会理论的方法论和认识论原则。
Modeling conflict and error in the medial frontal cortex.
  • DOI:
    10.1002/hbm.21405
  • 发表时间:
    2012-12
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Mayer, Andrew R.;Teshiba, Terri M.;Franco, Alexandre R.;Ling, Josef;Shane, Matthew S.;Stephen, Julia M.;Jung, Rex E.
  • 通讯作者:
    Jung, Rex E.
The neural networks underlying auditory sensory gating.
  • DOI:
    10.1016/j.neuroimage.2008.08.025
  • 发表时间:
    2009-01-01
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Mayer AR;Hanlon FM;Franco AR;Teshiba TM;Thoma RJ;Clark VP;Canive JM
  • 通讯作者:
    Canive JM
Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders.
可卡因使用障碍中增强的提示反应性和额叶功能连通性。
  • DOI:
    10.1016/j.drugalcdep.2011.01.009
  • 发表时间:
    2011-05-01
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Wilcox, Claire E.;Teshiba, Terri M.;Merideth, Flannery;Ling, Josef;Mayer, Andrew R.
  • 通讯作者:
    Mayer, Andrew R.
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Andrew Robert Mayer其他文献

Andrew Robert Mayer的其他文献

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{{ truncateString('Andrew Robert Mayer', 18)}}的其他基金

Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)
III 期 COBRE:神经精神疾病 (MIND) 的多模态成像
  • 批准号:
    10372242
  • 财政年份:
    2018
  • 资助金额:
    $ 25.7万
  • 项目类别:
Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)
III 期 COBRE:神经精神疾病 (MIND) 的多模态成像
  • 批准号:
    10324137
  • 财政年份:
    2018
  • 资助金额:
    $ 25.7万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10324141
  • 财政年份:
    2018
  • 资助金额:
    $ 25.7万
  • 项目类别:
Algorithm and Data Analysis (ADA) Core
算法和数据分析 (ADA) 核心
  • 批准号:
    10324140
  • 财政年份:
    2018
  • 资助金额:
    $ 25.7万
  • 项目类别:
Pilot Project Program (PPP)
试点项目计划(PPP)
  • 批准号:
    10324142
  • 财政年份:
    2018
  • 资助金额:
    $ 25.7万
  • 项目类别:
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in Children
弥漫性轻度脑损伤对儿童临床结果的影响
  • 批准号:
    9685257
  • 财政年份:
    2016
  • 资助金额:
    $ 25.7万
  • 项目类别:
The Impact of Diffuse Mild Brain Injury on Clinical Outcomes in Children
弥漫性轻度脑损伤对儿童临床结果的影响
  • 批准号:
    9185679
  • 财政年份:
    2016
  • 资助金额:
    $ 25.7万
  • 项目类别:
A Multidimensional Investigation of Cognitive Control Deficits in Psychopathology
精神病理学中认知控制缺陷的多维调查
  • 批准号:
    8899274
  • 财政年份:
    2014
  • 资助金额:
    $ 25.7万
  • 项目类别:
A Multidimensional Investigation of Cognitive Control Deficits in Psychopathology
精神病理学中认知控制缺陷的多维调查
  • 批准号:
    8691200
  • 财政年份:
    2014
  • 资助金额:
    $ 25.7万
  • 项目类别:
Attentional Bias Modification: Efficacy and Mechanisms of Action in Cocaine Addic
注意偏差修正:可卡因成瘾者的功效和作用机制
  • 批准号:
    8190807
  • 财政年份:
    2012
  • 资助金额:
    $ 25.7万
  • 项目类别:

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