Epidemiology of Prescription Drug Abuse in the United States

描述(由申请人提供)： R03对NIDA的应用是对RFA-DA-05-005，NESARC和NSPY数据集的二次分析的响应；我们建议对两个国家数据集进行二次分析，以检查(1)非医疗用处方药(NMPD)和处方药使用障碍(PDUD)的流行率和相关性，(2)伴随NMPD和酒精使用(包括酒精使用障碍(AUD))的流行率和相关性，以及(3)1991-1992年至2001-2002年美国NMPD和其他药物使用的开始年龄。在过去的十年里，几类受控物质(如抗焦虑药、阿片类镇痛剂、镇静剂/催眠药和兴奋剂)的非医疗用途在美国有所增加。虽然伴随NMPD和酒精的使用有许多潜在的后果，但这两种物质使用行为之间的联系在基于人口的全国研究中很少受到关注。为了弥补这些差距，我们提议对1991-1992年全国酒精及相关疾病流行病学调查(NLAES)和2001-2002年全国酒精及相关疾病流行病学调查(NESARC)进行二次分析；每个调查都具有全国代表性的大样本，约43,000名美国18岁及以上的成年人。NLAES和NESARC的数据集将使用统计软件包进行分析，该软件包在进行多变量分析的同时考虑了复杂的样本设计。拟议项目的具体目的是评估：(1)1991-1992年和2001-2002年期间NMPD和PDUD的患病率及其相关性的趋势；(2)1991-1992年和2001-2002年期间NMPD和酒精使用以及(B)伴随的PDUD和AUD的患病率和相关性的趋势；以及(3)1991-1992年和2001-2002年期间NMPD和其他药物使用的开始年龄的趋势。这项研究的结果将加深我们对处方药的非医疗使用、处方药使用障碍和新出现的物质使用形式的理解。这将有助于确定药物滥用的风险因素。最重要的是，研究结果将为预防、评估和治疗处方药滥用提供指导。

DESCRIPTION (provided by applicant): This R03 application to NIDA is in response to RFA-DA-05-005, Secondary Analysis of the NESARC and NSPY Datasets; we propose a secondary analysis of two national datasets to examine the trends in (1) the prevalence and correlates of nonmedical use of prescription drugs (NMPD) and prescription drug use disorders (PDUD), (2) the prevalence and correlates of concomitant NMPD and alcohol use, including alcohol use disorders (AUD), and (3) age of initiation of NMPD and other drug use in the U.S. between 1991- 1992 and 2001-2002. The nonmedical use of several classes of controlled substances (e.g., anxiolytics, opioid analgesics, sedative/hypnotics, and stimulants) has increased in the past decade in the U.S. While there are many potential consequences associated with concomitant NMPD and alcohol use, the association between these two substance use behaviors has received very little attention in national population-based research. In order to address these gaps, we propose to conduct a secondary analysis of the 1991-1992 National Longitudinal Alcohol Epidemiogical Survey (NLAES) and the 2001-2002 National Epidemiology Survey on Alcohol and Related Conditions (NESARC); each feature large nationally representative samples of approximately 43,000 adults 18 years of age and older in the U.S. The NLAES and NESARC datasets will be analyzed using a statistical software package capable of taking a complex sample design into account while performing multivariate analyses. The specific aims of the proposed project are to assess: (1) trends in the prevalence and correlates of NMPD and PDUD between 1991-1992 and 2001-2002; (2) trends in prevalence and correlates of (a) concomitant NMPD and alcohol use and (b) concomitant PDUD and AUD between 1991-1992 and 2001-2002; and (3) trends in age of initiation of NMPD and other drug use between 1991-1992 and 2001-2002. The findings of this study will enhance our understanding of nonmedical use of prescription drugs, prescription drug use disorders and emerging forms of substance use. It will help identify risk factors for substance abuse. Most importantly, the findings will provide guidance for the prevention, assessment, and treatment of prescription drug abuse.