Trajectories of Nonmedical Prescription Drug Misuse

非医疗处方药滥用的轨迹

• 批准号: 9096030
• 负责人: SEAN ESTEBAN MCCABE
• 金额: $ 23.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096030
• 关键词: 21 year old; Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; Applications Grants; Data; Development; Drug abuse; Epidemiology; Future; Health; Health Professional; Heterogeneity; Hospitalization; Individual; Investigation; Knowledge; Lead; Legal; Longitudinal Studies; Measurement; Measures; Medical; Medication Management; Modeling; Monitor; NIH Program Announcements; Opioid; Parents; Pattern; Pharmaceutical Preparations; Prevention; Recording of previous events; Research; Research Design; Risk; Sample Size; Sampling; Schedule; Socioeconomic Status; Substance Use Disorder; Testing; Tranquilizing Agents; United States Substance Abuse and Mental Health Services Administration; Work; adverse outcome; aged; base; clinical practice; cohort; improved; meetings; misuse of prescription only drugs; nonmedical use; opioid use; prescription drug abuse; prescription opioid; prospective; response; sedative; sex; theories; twelfth grade; young adult

 DESCRIPTION (provided by applicant): In response to PA-13-080: Accelerating the Pace of Drug Abuse Research Using Existing Research Data, this competing renewal "Trajectories of Nonmedical Prescription Drug Misuse" builds on our parent R01 and proposes to use multiple cohorts of nationally representative longitudinal data to assess the individual patterns and trajectories of medical and nonmedical use of four classes of prescription medications (i.e., opioids, sedatives, stimulants, tranquilizers) from adolescence to adulthood and the development of substance use disorders (SUDs) and other long-term adverse consequences in adulthood. Despite increases in the medical and nonmedical use of prescription medications among adolescents and young adults in the U.S., relatively few prospective longitudinal studies have investigated the development of SUDs and other adverse consequences in adulthood. While there have been advances in understanding nonmedical use of prescription medications and short-term consequences, considerable gaps in knowledge remain due to limitations in measurement and study designs. Findings from our parent R01 suggest a great deal of heterogeneity in the nonmedical use of prescription medications during adolescence and young adulthood (ages 18-22). The Monitoring the Future (MTF) study provides a valuable opportunity to address new research questions that will lead to a more comprehensive understanding of medical and nonmedical use of prescription medications. We propose several secondary analyses using 39 nationally representative cohorts of approximately 585,000 high school seniors between 1976 and 2014 from the MTF study. The MTF longitudinal panel sample features 23 separate cohorts of approximately 55,200 high school seniors (modal age 18) who were followed 3-4 years (modal ages 21-22), 7-8 years (modal ages 25-26), and 17 years (modal age 35) later, resulting in four longitudinal waves of data for each cohort. The MTF study represents the only nationally representative longitudinal study that has sufficient measures and sample size to test for potential sex, racial, and socioeconomic status differences and to meet the objectives of our study, which aims to: 1) assess the individual patterns and trajectories of medical and nonmedical use of four prescription medication classes (i.e., opioids, sedatives, stimulants, tranquilizers) during the transition from adolescence (age 18) to adulthood (age 35) using cross-sectional and longitudinal panel data; 2) examine the associations between individual patterns and trajectories of medical and nonmedical use of four medication classes from adolescence to adulthood and development of SUDs and other adverse consequences (e.g., health problems, hospitalizations, and legal problems) during adulthood (age 35) using longitudinal panel data; and 3) investigate the risk and protective factors for individual patterns and trajectories of medical and nonmedical use of four prescription medication classes from adolescence to adulthood associated with development of SUDs and other consequences during adulthood (age 35) using a theory-based developmental model and longitudinal panel data.

 描述(申请人提供)：为响应PA-13-080：利用现有研究数据加快药物滥用研究的步伐，这一相互竞争的更新“非医疗处方药滥用的轨迹”建立在我们的母公司R01的基础上，并建议使用多个具有全国代表性的纵向数据队列来评估四类处方药(即阿片类药物、镇静剂、兴奋剂、镇静剂)从青春期到成年期的医疗和非医疗用药的个体模式和轨迹，以及成年期物质使用障碍(SUD)和其他长期不良后果的发展。尽管在美国青少年和年轻人中使用处方药的医疗和非医疗用途有所增加，但相对较少的前瞻性纵向研究调查了肥皂水症的发展和成年后的其他不良后果。虽然在理解处方药的非医疗用途和短期后果方面已经取得了进展，但由于测量和研究设计的限制，在知识方面仍然存在相当大的差距。我们的父母R01的研究结果表明，青春期和成年期(18-22岁)非医疗处方药的使用存在很大的异质性。监测未来(MTF)研究提供了一个宝贵的机会来解决新的研究问题，这将导致更全面地了解处方药的医疗和非医疗用途。我们从MTF研究中提出了几个二级分析，使用了来自MTF研究的大约585,000名高中生的39个全国代表性队列。MTF纵向面板样本包括大约55,200名高中生(18岁)的23个独立队列，他们在3-4年(模型年龄21-22岁)、7-8年(模型年龄25-26岁)和17年(模型年龄35岁)之后进行跟踪，导致每个队列的四个数据纵向波动。MTF研究代表了唯一具有全国代表性的纵向研究，具有足够的措施和样本量来测试潜在的性别、种族和社会经济地位差异，并满足我们研究的目标，其目的是：1)使用横断面和纵向小组数据评估从青春期(18岁)到成年期(35岁)期间四种处方药类别(即阿片类药物、镇静剂、兴奋剂、镇静剂)的个人模式和非医疗使用轨迹；2)使用纵向面板数据检验从青春期到成年期的四种药物类别的医疗和非医疗使用的个体模式和轨迹与成年期(35岁)期间肥皂泡的发展和其他不良后果(例如，健康问题、住院和法律问题)之间的关系；以及3)调查个体模式的风险和保护因素 以及使用基于理论的发展模型和纵向面板数据，从青春期到成年期(35岁)与肥皂泡和其他后果相关的四种处方药类别的医疗和非医疗使用轨迹。