Longitudinal Changes in Recovery from Drug Use Disorders: A National Study

吸毒障碍康复的纵向变化：一项全国研究

基本信息

批准号：
9220789
负责人：
SEAN ESTEBAN MCCABE
金额：
$ 21.62万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-03-01 至 2019-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9220789
关键词：
18 year old Address Admission activity Adolescence Adult Age Alcohols Attention Cannabis Childhood Cocaine Comorbidity Data Development Disease remission Drug Abuse Treatment Services Drug Use Disorder Drug Utilization Drug abuse Drug user Epidemiology Ethnic Origin Gender General Population Hallucinogens Heroin Individual Inhalant dose form Investigation Knowledge Longitudinal Studies Longitudinal Surveys Marijuana Measures Mental Health Mental disorders Methodology Opiates Opioid Pattern Pharmaceutical Preparations Pharmacoepidemiology Prevalence Preventive Intervention Prospective Studies Public Health Race Recovery Recurrence Relapse Reporting Research Sample Size Sampling Sex Characteristics Social Functioning Surveys Time Tranquilizing Agents age difference alcohol and other drug alcohol use disorder base clinical practice disability drug abstinence drug of abuse improved physical conditioning public health relevance racial difference relapse prediction relapse risk secondary analysis sedative time use treatment center treatment program

项目摘要

DESCRIPTION (provided by applicant): This project "Longitudinal Changes in Recovery from Drug Use Disorders: A National Study" proposes to use two waves of nationally representative longitudinal data to examine the course of drug use disorders (DUDs) along with longitudinal changes in recovery from DUDs, including rates and correlates of relapse (i.e., recurrence of any DUD criteria) and full remission (i.e., no recurrence of any DUD criteria). To date, there is limited knowledge on the stability of full remission from DUDs based on nationally representative studies in the U.S. because the majority of research has focused solely on alcohol use disorders (AUDs) and treatment samples. There has been a significant shift in primary drugs of abuse observed in those entering drug abuse treatment programs in the U.S. over the past two decades with the percentage of drug abuse treatment admissions reporting alcohol as the primary drug of abuse decreasing from 57% in 1993 to 41% in 2010, while the percentage of drug abuse treatment admissions for marijuana, opiates, and stimulants increased from approximately 22% in 1993 to 47% in 2010. While the course of AUDs and recovery from AUDs has been well-investigated in the general population, no nationally representative studies have examined the longitudinal patterns of DUDs and recovery from DUDs over time and potential differences between DUDs involving individual drug classes (e.g., sedative, tranquilizer, opioid, stimulant, hallucinogen, cannabis, cocaine, heroin, and inhalant) o DUDs involving multiple drug classes. In order to address these gaps, we propose a secondary analysis of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a two-wave longitudinal and epidemiological survey of a nationally representative sample of 34,653 non-institutionalized adults, 18 years of age or older residing in the U.S. The NESARC represents the only large-scale nationally representative study that has a sufficient sample size to assess potential differences in drug classes, age, gender, and race/ethnicity, to meet our study purpose which aims to: (1) assess the prevalence of recovery from DUDs (i.e., drug-specific DUDs and DUDs involving multiple drug classes) at Wave 1 (baseline) and Wave 2 (3 years later); (2) determine whether DUD recovery status at Wave 1 (baseline) is associated with the likelihood of reinterview at Wave 2 (3 years later), and examine the sensitivity of inferences regarding DUD recovery status at Wave 2 to potential differential attrition; (3) examine the predictors from multiple developmental domains associated with relapse and full remission; and (4) investigate the effects of drug abuse treatment utilization and disability on recovery from DUDs at Waves 1 and 2. The proposed project takes advantage of the unique opportunities afforded by the NESARC. These include: the availability of a large nationally representative sample of non-institutionalized adults; large numbers of individuals with DUD; the inclusion of developmentally relevant predictors associated with relapse; and the inclusion of reliable measures of disability, treatment utilization, DUDs and other psychiatric disorders.

DESCRIPTION (provided by applicable): This project "Longitudinal Changes in Recovery from Drug Use Disorders: A National Study" proposals to use two waves of nationally representative longitudinal data to examine the course of drug use disorders (DUDs) along with longitudinal changes in recovery from DUDs, including rates and correlates of relief (i.e., recurrence of any DUD criteria) and full remission (i.e., no recurrence of any DUD 标准）。迄今为止，基于美国国家代表性研究的duds完全缓解的稳定性的知识有限，因为大多数研究仅集中在酒精使用障碍（AUD）和治疗样本上。在过去的二十年中，在美国进入药物滥用治疗计划的人中观察到的主要滥用药物的主要变化发生了重大变化，滥用药物治疗的百分比报道了酒精作为滥用的主要药物从1993年的57％降低到2010年的41％降低到2010年的41％，而在1993年中，在1993年中，在1993年中，滥用药物滥用治疗的百分比增长了，降低了1993％的频率，降低了1993％的速度和刺激性。 AUDS在普通人群中受到了良好的投资，所有国家代表性的研究都没有研究过duds的纵向模式，并随着时间的流逝而从duds中恢复过来，涉及单个药物类别的DUD（例如，镇静剂，替身者，阿片类药物，阿片类药物，刺激性，刺激剂，刺激性，刺激性，大麻，cocabis，Cocaine，Cocaine，Cocaine，cultrant crupters oteral oferation of Meration and Healant and Healant and Healant和inalantants oduds od duds）O.为了解决这些差距，我们提出了对酒精和相关条件的国家流行病学调查（NESARC）的次要分析（NESARC），这是对34,653个非机构化成年人的全国代表性样本进行的两波纵向和流行病学调查，该样本是NESARC的规模，以表现出较大的国家，以表明其在美国的规模较高，以表明其在美国的规模较高，而较大的型号则是在美国的规模范围。阶级，年龄，性别和种族/种族/种族/种族，以满足我们的学习目的，目的是：（1）评估在第1波（基线）（基线）和第2波（3年后）在Duds（即涉及多个药物类别）的DUD（即涉及多个药物类别）的恢复率的普遍性；（2）确定第1波（基线）处的DUD恢复状态是否与第2波（3年后）进行审查的可能性有关，并检查推断对第2次dud恢复状态的推论敏感性与潜在的微分属性；（3）检查与救济和完全缓解相关的多个发展领域的预测因素；（4）调查药物滥用治疗利用和残疾对波浪1和2的恢复的影响。拟议的项目利用了NESARC提供的独特机会。其中包括：可获得大量全国性代表性的非机构化成年人样本；大量有傻瓜的人；包括与救济相关的发展相关预测因素；以及包括可靠的残疾，治疗利用，DUD和其他精神疾病的措施。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Sources of opioid medication for misuse in older adults: results from a nationally representative survey.

DOI：
10.1097/j.pain.0000000000001241
发表时间：
2018-08
期刊：
Pain
影响因子：
7.4
作者：
Schepis TS;McCabe SE;Teter CJ
通讯作者：
Teter CJ

Associations Among Childhood Household Dysfunction, Sexual Orientation, and DSM-5 Alcohol, Tobacco and Other Substance Use Disorders in Adulthood: Evidence From a National U.S. Survey.

DOI：
10.1097/adm.0000000000000641
发表时间：
2020
期刊：
Journal of addiction medicine
影响因子：
5.5
作者：
McCabe SE;Hughes TL;West BT;Evans-Polce R;Veliz P;Dickinson K;Hoak S;Boyd CJ
通讯作者：
Boyd CJ

Prescription opioid and benzodiazepine misuse is associated with suicidal ideation in older adults.