E-Cigarette Use and Longitudinal Changes in Cigarette Smoking and Health

电子烟的使用以及吸烟与健康的纵向变化

• 批准号: 9339655
• 负责人: SEAN ESTEBAN MCCABE
• 金额: $ 21.74万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339655
• 关键词: Address; Adolescence; Adolescent; Age; Age of Onset; Alcohol or Other Drugs use; Behavior; Cause of Death; Cessation of life; Characteristics; Cigarette; Cigarette Smoker; Data; Data Analyses; Development; Disease; Drug abuse; Electronic cigarette; Enrollment; Epidemiology; Ethnic Origin; Exposure to; Frequencies; Future; Gender; Health; Health Policy; High Prevalence; High School Student; Knowledge; Lead; Long-Term Effects; Longitudinal Studies; Measures; Methodology; Modality; Monitor; Natural History; Nicotine; Outcome; Pattern; Prevalence; Prevention; Preventive Intervention; Privatization; Public Health; Race; Recording of previous events; Research; Risk; Risk Factors; Sample Size; Sampling; School-Age Population; Secondary Schools; Smoke; Smoking; Smoking and Health Research; Socioeconomic Status; Students; Subgroup; Surveys; Testing; Time; Tobacco use; Weight; Youth; adolescent smoking; age effect; age group; base; cigarette smoking; clinical practice; cohort; disability; high school; improved; premature; public health relevance; rate of change; secondary analysis; service intervention; sex; smoking cessation; tenth grade; twelfth grade; young adult

 DESCRIPTION (provided by applicant): This project, entitled "E-Cigarette Use and Longitudinal Changes in Cigarette Smoking and Health" proposes to use three waves of nationally representative longitudinal data to examine the relationships among e-cigarette use, traditional cigarette smoking, other tobacco use, other substance use behaviors and health problems from adolescence to young adulthood. E-cigarette use has increased significantly between 2011 and 2014 among U.S. adolescents and has surpassed the current use of traditional cigarette smoking among adolescents. In 2014, more than one in every six U.S. high school seniors used e- cigarettes in the past month. Never-smoking adolescents who have used e-cigarettes are twice more likely to say they intend to smoke traditional cigarettes than never-smoking youth who have not used e-cigarettes. Traditional cigarette smoking is most prevalent among young adults following high school (ages 18-24) relative to all other age groups. Tobacco use remains the leading preventable cause of death, and traditional cigarette smoking is responsible for more than 480,000 deaths per year in the U.S. This raises important public health questions regarding the long-term effects of e-cigarette use: 1) Does e-cigarette use change the risk for subsequent traditional cigarette smoking, other tobacco use, and health problems? 2) Are traditional cigarette smokers more likely to quit smoking after initiating e-cigarette use? To date, the long-term patterns and consequences associated with e-cigarette use in nationally representative samples of adolescents have not been studied. To address these gaps in knowledge, we will conduct a secondary analysis of data from the Monitoring the Future (MTF) study, a multi-cohort epidemiological survey of a sample of approximately 142,500 students enrolled in U.S. private/public secondary schools. The MTF study also features a longitudinal panel sample of high school seniors (modal age: 18 years) who were followed 1-2 years (modal ages: 19-20 years) and 3-4 years (modal ages: 21-22 years) after high school, resulting in three waves of longitudinal data. Several new questions were recently added to the MTF study to assess e-cigarette use. As a result, the MTF has sufficient measures and sample size to test for potential gender, race/ethnicity, and socioeconomic status differences in e-cigarette use and its consequences. Our study aims to: (1) estimate the bias in estimated rates of e-cigarette use and traditional cigarette smoking in adolescence and young adulthood and estimated rates of change over time in e-cigarette use and traditional cigarette smoking due to differential attrition in the MTF study, by comparing and evaluating alternative weighting and imputation approaches; (2) examine the trajectories of e-cigarette use, traditional cigarette smoking, other tobacco use, other substance use behaviors, and health problems from adolescence to young adulthood as a function of e-cigarette use history at age 18; and (3) assess the effects of age of onset and frequency of e-cigarette use on the trajectories of traditional cigarette smoking, other tobacco use, other substance use behaviors, and health problems.

 描述（由申请人提供）：该项目题为“电子烟使用和吸烟与健康的纵向变化”，建议使用三波具有全国代表性的纵向数据来检查从青少年到青年的电子烟使用，传统香烟吸烟，其他烟草使用，其他物质使用行为和健康问题之间的关系。2011年至2014年间，美国青少年使用电子烟的人数显著增加，超过了目前青少年使用传统香烟的人数。2014年，每6名美国高中毕业生中就有超过1人在过去一个月内使用过电子烟。使用过电子烟的从不吸烟的青少年说他们打算吸传统香烟的可能性是没有使用过电子烟的从不吸烟的青少年的两倍。相对于所有其他年龄段，传统吸烟在高中后的年轻人（18-24岁）中最为普遍。烟草使用仍然是主要的可预防的死亡原因，在美国，传统吸烟每年导致超过48万人死亡。这就提出了关于电子烟用途：1）电子烟使用是否会改变随后传统吸烟、其他烟草使用和健康问题的风险？2)传统吸烟者在开始使用电子烟后更有可能戒烟吗？到目前为止，尚未研究全国代表性青少年样本中与电子烟使用相关的长期模式和后果。为了解决这些知识差距，我们将对监测未来（MTF）研究的数据进行二次分析，这是一项多队列流行病学调查，样本约为142，500名美国私立/公立中学学生。MTF研究还包括高中毕业生（模态年龄：18岁）的纵向面板样本，他们在高中毕业后被跟踪1-2年（模态年龄：19-20岁）和3-4年（模态年龄：21-22岁），产生三波纵向数据。MTF研究最近增加了几个新问题，以评估电子烟的使用。因此，MTF有足够的措施和样本量来测试电子烟使用及其后果的潜在性别，种族/民族和社会经济地位差异。我们的研究旨在：（1）通过比较和评估替代加权和插补方法，估计青春期和青年期电子烟使用率和传统吸烟率的估计偏差，以及MTF研究中由于差异损耗导致的电子烟使用率和传统吸烟率随时间推移的估计变化率;（2）检查电子烟使用的轨迹，传统的吸烟，其他烟草使用，其他物质使用行为，以及从青春期到青年期的健康问题，作为18岁时电子烟使用史的函数;（3）评估发病年龄和电子烟使用频率对传统吸烟、其他烟草使用、其他物质使用行为和健康问题轨迹的影响。