TRAINING IN MOLECULAR PATHOGENESIS OF MICROBIAL DISEASES

微生物疾病分子发病机制培训

• 批准号: 7278795
• 负责人: Dennis Edward Ohman
• 金额: $ 17.31万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278795
• 关键词: TRAINING; MOLECULAR; PATHOGENESIS; MICROBIAL; DISEASES

DESCRIPTION (provided by applicant): The major goal of this continuing training program is to provide graduate students and postdoctoral fellows with a first-rate training experience in preparation for careers as competitive, independent investigators in scientific research, particularly at biomedical institutions. As part of this goal, we will recruit talented and motivated students and postdoctoral fellows that are dedicated to biomedical research. New scientists are needed in the area of molecular pathogenesis because future success in the prevention and treatment of new, resurgent, and antibiotic-resistant infectious agents will require a sophisticated understanding of the molecular basis of pathogenesis. The training program focuses on understanding molecular mechanisms of pathogenesis, host-microbe interactions, and the use of molecular biology, genomic and bioinformatic technology to study pathogenesis. This training program is directed individually by research advisors and overall by a program governance committee. Training includes rigorous laboratory research, weekly seminars, local meetings, and advanced courses. A major strength is the quality of the research programs of the 10 well-funded program faculty members from 4 departments who have productive and energetic research efforts in numerous areas of current interest. The Molecular Pathogenesis Group is highly interactive, and trainees are regularly exposed to diverse areas of research on bacteria (gonococci, obligate anaerobes, pseudomonades, spirochetes, staphylococci, streptococci), protozoan (amoebae, trypanosomes), fungal (Cryptococcus, Pneumocystis), and viral (cytomegalovirus, hepatitis, herpesvirus) pathogens using the full range of modern molecular techniques. The training program also benefits from the presence of a strong graduate program in the School of Medicine of VCU. Trainees benefit from vigorous faculty involvement, experiences in communicating their work, and excellent core facilities, all of which provide a superb environment for training the next generation of researchers in molecular pathogenesis.

描述（由申请人提供）：该继续培训计划的主要目标是为研究生和博士后研究员提供一流的培训经验，为他们在科学研究领域（特别是在生物医学机构）成为有竞争力的独立研究人员做好准备。作为这一目标的一部分，我们将招募有才华、积极进取的学生和博士后，致力于生物医学研究。分子发病机制领域需要新的科学家，因为未来要成功预防和治疗新的、复活的和抗生素耐药的感染原，将需要对发病机制的分子基础有深入的了解。培训计划的重点是了解发病机制的分子机制、宿主与微生物的相互作用，以及利用分子生物学、基因组和生物信息技术来研究发病机制。该培训计划由研究顾问单独指导，并由项目管理委员会总体指导。培训包括严格的实验室研究、每周研讨会、当地会议和高级课程。主要优势在于来自 4 个系的 10 名资金充足的项目教员的研究项目质量，他们在当前感兴趣的众多领域进行了富有成效和充满活力的研究工作。分子发病机制小组互动性很强，学员定期接触细菌（淋球菌、专性厌氧菌、假单胞菌、螺旋体、葡萄球菌、链球菌）、原生动物（变形虫、锥虫）、真菌（隐球菌、肺孢子虫）和病毒的不同研究领域 （巨细胞病毒、肝炎、疱疹病毒）病原体采用全方位的现代分子技术。该培训计划还得益于弗吉尼亚联邦大学医学院强大的研究生课程。受训者受益于教师的积极参与、工作交流的经验以及优良的核心设施，所有这些都为培训下一代分子发病机制研究人员提供了极好的环境。