TRAINING IN MOLECULAR PATHOGENESIS OF MICROBIAL DISEASES

微生物疾病分子发病机制培训

• 批准号: 6653257
• 负责人: Dennis Edward Ohman
• 金额: $ 17.09万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653257
• 关键词: TRAINING; MOLECULAR; PATHOGENESIS; MICROBIAL; DISEASES

DESCRIPTION (adapted from the application): The major goal of this proposed training program is to provide graduate students and postdoctoral fellow with a first-rate training experience as preparation for careers as competitive, independent investigators in scientific research, particularly at biomedical institutions. As part of this goal, we will recruit talented and motivated students and fellows that are dedicated to biomedical research. The program will focus on training in molecular mechanisms of pathogenesis, in understanding host-microbe interactions, and in how to use the new scientific culture of genomics and bioinformatics. New scientists are needed in the area of molecular pathogenesis because infectious diseases are still the most frequent cause of death in the developing world and still cause significant morbidity and mortality in developing countries. Future success in the identification prevention, and treatment of new or resurgent infectious agents, that are often antibiotic resistant, will require sophisticated understanding of the molecular basis of pathogenesis and the molecular biology of pathogenic microbes. This training program is directed individually by research advisors and overall by a program governance committee that will measure the success of the program. Training in molecular pathogenesis includes laboratory research, weekly seminar series, retreats and advanced well-developed courses. This program provides a multidisciplinary research environment in addition to formal instruction in molecular pathogenesis, biochemistry, genetics, microbiology and other fields. The training program proposed is for five predoctoral and five postdoctoral trainees at the Ph.D., M.D., and D.O. levels. Trainees are regularly exposed to diverse areas of research on bacterial (gonococci, obligate anaerobes, pseudomonads, spirochaetes, staphylococci and streptococci), viral (cytomegalovirus, hepatitis, and herpesvirus), fungal (Cryptococcus and Pneumocystis), and protozoan (amebae and trypanosomes) pathogens using the full range of modern molecular techniques. The proposal benefits from the presence of an interdisciplinary graduate program at VCU-MCV.

描述（改编自应用程序）：本建议的主要目标 培养计划是为研究生和博士后研究员提供 一流的培训经验，为竞争激烈的职业生涯做准备， 科学研究中的独立调查员，特别是在生物医学领域 机构职能体系作为这一目标的一部分，我们将招募有才华和有动力的人， 致力于生物医学研究的学生和研究员。程序 将重点培训发病机制的分子机制， 了解宿主-微生物的相互作用，以及如何使用新的科学 基因组学和生物信息学文化。该地区需要新的科学家 因为传染病仍然是 这是发展中国家常见的死亡原因， 发病率和死亡率。未来的成功 识别、预防和治疗新发或复发传染病 通常具有抗生素耐药性的药物， 了解发病机制的分子基础和分子生物学 致病微生物的数量该培训计划由以下人员单独指导： 研究顾问和总体上由一个计划管理委员会， 衡量项目的成功。分子发病机制培训 包括实验室研究，每周研讨会系列，务虚会和高级 完善的课程。该计划提供了多学科的研究 环境除了分子发病机理的正式指导外， 生物化学、遗传学、微生物学等领域。培训计划 建议为五名博士预科生和五名博士后研究生提供博士学位， 医学博士，和D.O.程度.学员经常接触到不同领域的 对细菌（淋球菌，专性厌氧菌，假单胞菌， 螺旋体，葡萄球菌和链球菌），病毒（巨细胞病毒， 肝炎和疱疹病毒），真菌（隐球菌和肺孢子虫），和 原生动物（阿米巴和锥虫）病原体使用全方位的现代 分子技术该提案得益于一个 在VCU-MCV跨学科研究生课程。