NRSA Hepatology Training Grant

描述（由申请人提供）：肝病学博士后培训计划是加州大学旧金山分校肝脏相关研究的重要组成部分。该计划的目的是为学员提供肝脏生物学和疾病的全面背景，以及研究技能，以解决新问题并为肝病学的新知识做出贡献。该项目由内科、外科、生物化学、微生物与免疫学等13个系组成；总的来说，这些人在基础和临床肝病学方面提供了平衡的专业知识，并且彼此之间有着良好的合作记录。一个由5名项目教师组成的小组组成了一个指导委员会，负责筛选申请人、审查培训课程和监督在职学员的进展。该计划的首要任务是培养被加州大学旧金山分校录取为胃肠病学研究员的内科科学家。该项目的医学博士申请者必须有先前的研究成就记录，并致力于肝病学的独立研究事业。博士申请者主要来自导师实验室；他们必须表现出类似的学术前景和对转化肝脏研究的方向。所有学员都将学习肝脏相关生物学、肝脏相关研究方法和一般学术技能等核心课程。然后，他们在个别导师的指导下接受专门的研究指导，从临床流行病学、健康结果和遗传学到细胞生物学、器官发生、免疫学、代谢和纤维化/癌变。强烈建议所有学员参加额外的重点课程；对于那些从事临床研究的人来说，注册硕士学位课程是强制性的。重要的是，培训计划受益于众多机构资源，包括基础和临床科学领域的优秀研究生课程，以及肝脏中心和临床与转化科学研究所等研究支持单位。项目教师在这些单元中都是强有力的人物，因此可以指导受训者利用这些资源来最大化他们博士后经历的价值。培训计划的最终目标是提供足够的团体和个人指导，使毕业生能够担任教师级别的职位，并成功地竞争独立的肝病学研究经费。

DESCRIPTION (provided by applicant): The Postdoctoral Training Program in Hepatology is an integral part of the robust liver-related research effort at UCSF. The purpose of the Program is to provide trainees a comprehensive background in liver biology and disease as well as the investigational skills to address new questions and contribute to new knowledge in hepatology. The Program is staffed by 13 faculty based within the Departments of Medicine, Surgery, Biochemistry and Microbiology & Immunology; collectively these individuals offer balanced expertise in basic and clinical hepatology and have a strong track record of working collaboratively with each other. A subgroup of 5 Program faculty comprise a Steering Committee charged with screening applicants, reviewing the training curriculum and monitoring the progress of active trainees. The top priority of the Program is to train physician- scientists who are admitted to UCSF as Gastroenterology fellows. MD applicants to the Program must have a prior record of research accomplishment and dedication to an independent investigative career in hepatology. PhD applicants are admitted largely from mentor laboratories; they must display similar academic promise and an orientation toward translational liver research. All trainees are placed through a core curriculum covering liver-related biology, liver-related research methods and general academic skills. They then undergo specialized research instruction under an individual mentor, with choices ranging from clinical epidemiology, health outcomes and genetics to cell biology, organogenesis, immunology, metabolism and fibrosis/carcinogenesis. Additional focused coursework is highly recommended for all trainees; for those pursuing clinical investigation, enrollment in a Master's Degree program is mandatory. Importantly, the Training Program benefits from numerous institutional resources including outstanding graduate programs in basic and clinical sciences as well as research support units such as the Liver Center and the Clinical and Translational Sciences Institute. Program faculty are strong figures in each of these units, and accordingly can guide trainees to utilize these resources to maximize the value of their postdoctoral experience. The ultimate goal of the Training Program is to provide sufficient group and individual mentorship to enable graduates to assume a faculty-level position and compete successfully for independent research funding in hepatology.