Training Grant in Glomerular Function and Disease

描述(由申请人提供)： 这是对MUSC肾小球功能和疾病培训补助金的更新申请，该基金为有前途的博士后研究员提供与正常肾小球细胞生理和影响肾小球的疾病的发病机制相关的密集研究培训。我们的目标是培养以学术为导向的医生和在影响肾脏的疾病方面具有研究专长的基础科学家。该计划将提供基础、应用和临床研究方面的培训机会，使我们的学员能够发展在调查医学方面出类拔萃所需的技能。培训将强调糖尿病和高血压等系统性疾病与肾脏局部因素之间的相互作用，这些因素可能调节肾小球病理的发展。这些目标将通过一群才华横溢的调查员的协调努力来实现，这些调查员具有经过证实的专业知识、对培训和指导的承诺、出色的生产力以及在目标领域内的良好合作。我们的教师拥有广泛的专业知识，将提供生理学、分子和细胞生物学、遗传学、生物化学、基因转录、转基因技术、基因治疗、蛋白质组学、光谱和临床试验方面的综合培训。对于拥有医学博士学位的学员，该计划将包括一年的临床培训[不受此拨款支持]，然后至少两年的研究培训[将由本申请中申请的资金支持]。所有受训人员都将被要求参加并完成有关研究、诚信和道德方面的具体课程。研究经验将通过正式的课程作业、研讨会和期刊俱乐部来补充。博士申请者将被要求具有高级推荐信的研究经验。事先接触肾脏检查将不是先决条件。所有申请者将被期望对该项目的目标有高度的承诺，并表达开始从事学术研究事业的意向。我们重视具有不同背景的学员与我们的跨学科参与者小组进行互动。我们的目标是培养出对肾小球功能障碍有广泛洞察力的优秀研究人员，并为了解进行性肾小球疾病做出重大贡献。

DESCRIPTION (provided by applicant): This is a renewal application for the MUSC Training Grant in Glomerular Function and Disease that provides intensive research training for promising post-doctoral fellows in areas that relate to normal glomerular cell physiology and the pathogenesis of diseases that affect the renal glomerulus. Our goal is to produce academically oriented physicians and basic scientists with investigative expertise in diseases that affect the kidney. This program will provide training opportunities in basic, applied, and clinical research that will allow our trainees to develop the skills requisite to excel in investigative medicine. Training will emphasize the interplay between systemic diseases such as diabetes and hypertension, and local factors in the kidney, which may regulate the development of glomerular pathology. These goals will be accomplished through the coordinated efforts of a talented group of investigators with proven expertise, commitment to training and mentorship, outstanding productivity, and well-established collaborations within the target areas. Our faculty has a wide range of expertise that will provide for integrated training in physiology, molecular and cell biology, genetics, biochemistry, gene transcription, transgenic technologies, gene therapy, proteomics, spectrometry and clinical trials. For trainees with M.D. degrees, the program will consist of one year of clinical training [not to be supported by this grant] followed by at least two years of research training [that will be supported by funds requested in this application]. All trainees will be required to attend and complete specific courses dealing with research integrity and ethics. Research experience will be supplemented by formal course work, seminars, and journal clubs. Ph.D. applicants will be required to have prior research experience with superior letters of recommendation. Prior exposure to renal investigation will not be a prerequisite. All applicants will be expected to have a high degree of commitment to the objectives of this program, and to express the intention to embark upon careers in academic investigation. We value trainees with diverse backgrounds for interactions with our interdisciplinary group of participants. Our aim is to produce outstanding investigators with a broad insight into glomerular dysfunction, and who will make significant contributions to the understanding of progressive glomerular disorders.