Improving Functioning in Peripheral Arterial Disease

改善周围动脉疾病的功能

• 批准号: 7272054
• 负责人: Mary McGrae McDermott
• 金额: $ 94.71万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-22 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7272054
• 关键词: Blood; Blood Vessels; Blood Viscosity; Blood flow; C-reactive protein; Clinical; Communities; Condition; Control Groups; Diabetes Mellitus; Educational Intervention; Effectiveness of Interventions; Equilibrium; Exercise; Exertion; Fasting; Fibrinogen; Future; Glucose; Hip region structure; Home environment; Impairment; Individual; Inflammatory; Insulin; Insulin Resistance; Interleukin-6; Intermittent Claudication; Intervention; Invasive; Knee; Knowledge; Laboratories; Leg; Lower Extremity; Measures; Medical; Muscle; Nursing Homes; Outcome; Outcome Measure; Outcome Study; Oxygen Consumption; Pain; Pain in lower limb; Participant; Patients; Perceived quality of life; Performance; Peripheral arterial disease; Persons; Physical activity; Placement; Plethysmography; Population; Principal Investigator; Public Health; Questionnaires; Randomized; Randomized Controlled Clinical Trials; Relative (related person); Resistance; Rest; Risk; Score; Speed; Symptoms; Testing; Time; Training; Training Programs; Upper arm; Viscosity; Walking; Woman; Work; base; brachial artery; cytokine; day; depressive symptoms; experience; foot; functional outcomes; geriatric depression; improved; improved functioning; interest; men; meter; mortality; nutrition; older men; older patient; programs; response

DESCRIPTION (provided by applicant): Our previous work demonstrates that functional limitations associated with peripheral arterial disease (PAD) are diverse and include slower walking speed, poorer walking endurance, and impaired balance as compared to persons without PAD. Although treadmill-walking exercise improves treadmill performance in patients with intermittent claudication (IC), treadmill performance does not correlate well with community walking ability in older men and women. In older patient populations without PAD, resistance training improves functioning and walking endurance, but this mode of exercise has not been sufficiently studied in PAD. Furthermore, although 65% to 70% of men and women with PAD are either asymptomatic or have exertional leg symptoms other than IC, to our knowledge no prior studies have assessed the effects of exercise interventions in PAD patients who do not have IC. The primary aim of this study is to determine whether a six-month supervised treadmill exercise program and a supervised lower extremity progressive resistance training program, respectively, improve lower extremity functioning compared to a nutrition control group among 150 PAD patients with and without IC. We hypothesize that participants in the treadmill walking exercise program and participants in the progressive resistance training program, respectively, will experience greater improvement in functional outcomes than participants in the nutrition control group. Our primary functional outcome measures in descending order of importance are six-minute walk distance and the summary performance score. The summary performance score is a composite measure of lower extremity functioning (usual walking speed, standing balance, and time required for five repeated chair rises) measured on a 0-12 scale that predicts future risk of nursing home placement, mobility loss, and mortality. In our secondary specific aims we will identify mechanisms by which the exercise interventions improve functioning in PAD. Mechanisms we will study include changes in blood viscosity, peak oxygen consumption (VO2), calf blood flow, brachial artery endothelial reactivity, and inflammatory cytokine levels. By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD.

描述（由申请人提供）：

项目成果

Perceived Versus Objective Change in Walking Ability in Peripheral Artery Disease: Results from 3 Randomized Clinical Trials of Exercise Therapy.

• DOI: 10.1161/jaha.120.017609
• 发表时间: 2021-06-15
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: McDermott MM;Tian L;Criqui MH;Ferrucci L;Greenland P;Guralnik JM;Kibbe MR;Li L;Sufit R;Zhao L;Polonsky TS
• 通讯作者: Polonsky TS

Activating peripheral arterial disease patients to reduce cholesterol: a randomized trial.

激活外周动脉疾病患者降低胆固醇：一项随机试验。

• DOI: 10.1016/j.amjmed.2010.11.032
• 发表时间: 2011
• 期刊: The American journal of medicine
• 作者: McDermott,MaryM;Reed,George;Greenland,Philip;Mazor,KathyM;Pagoto,Sherry;Ockene,JudithK;Graff,Rex;Merriam,PhilipA;Leung,Kathy;Manheim,Larry;Kibbe,MelinaR;Olendzki,Barbara;Pearce,WilliamH;Ockene,IraS
• 通讯作者: Ockene,IraS