Epidemiology of Aging and Dementia-Autopsy Research

衰老和痴呆的流行病学-尸检研究

基本信息

  • 批准号:
    7498799
  • 负责人:
  • 金额:
    $ 2.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-06-01 至 2011-07-31
  • 项目状态:
    已结题

项目摘要

This grant will support continuation and expansion of autopsy research on brain aging, dementia, cognitive decline, Parkinson's disease, and stroke in Japanese American men for whom a wealth of prospectively collected information is available by virtue of their long-standing participation in the Honolulu Heart Program and Honolulu-Asia Aging Study. The principal goal is to improve understanding of the pathologic processes that underlie these illnesses and impairments in late life, and to identify risk factors associated with the brain lesions that represent the essential pathogenic processes. As of March 2005 a total of 615 brain autopsies had been done. This number will increase by approximately 50% over the course of the upcoming 5 years. Analyses to date implicate ischemic cerebrovascular disease as the pathogenic process most frequently linked to dementia in this cohort (25% of cases) and identify multiple microinfarcts as the most specific and consistent indicator. Neurofibrillary tangles (NFT) and/or neuritic plaques (NP) are the dominant or sole lesions associated with dementia in 20% of the demented decedents. Cortical Lewy bodies account for 10%, hippocampal sclerosis for 4%, and mixed (co- dominant) lesions for 18% of the dementia cases. Abnormalities identified in the remaining demented decedents (23%) were limited to generalized atrophy, gliosis, and neuron loss - not implicating a specific pathogenic mechanism. In this population, prevention strategies that reduce the burden of NFT and NP without influencing the other processes would likely have a modest public health impact. Our findings suggest that highly effective prevention programs are likely to require simultaneous targeting of two or more of the underlying processes. Analyses employing neuropathologic lesions as endpoints are conducted in an effort to identify specific risk factors for specific underlying pathogenic processes as an essential preliminary step toward prevention. In addition to accruing additional autopsies, the proposed continuation will support efforts directed toward (1) studies of microvascular ischemic disease, (2) relationships between distributions and densities of microinfarcts and Alzheimer's lesions, (3) relationships between structural characteristics of Circle of Willis arteries and lesions in the brain parenchyma, and (4) identification of the major underlying pathogenic processes responsible for brain atrophy and gliosis, and identification of corresponding risk factors.
这笔赠款将支持继续和扩大对脑老化,痴呆症, 认知能力下降,帕金森氏病,和中风的日裔美国人,他们的财富, 由于他们长期参与檀香山的活动, 心脏计划和檀香山-亚洲老龄化研究。主要目标是提高对 这些疾病和晚年损伤的病理过程,并确定风险因素 与代表基本致病过程的脑部病变相关。截至2005年3月a 总共进行了615次脑解剖。这一数字将比2010年增加约50%。 未来五年的发展方向。迄今为止的分析表明,缺血性脑血管病是 在该队列中,最常与痴呆相关的致病过程(25%的病例),并确定了多种 微梗死作为最具体和一致的指标。神经纤维缠结(NFT)和/或神经炎 斑块(NP)是20%的痴呆患者中与痴呆相关的主要或唯一病变 死者皮质Lewy小体占10%,海马硬化占4%,混合型(共- 显性)病变的18%的痴呆症病例。在剩下的痴呆症患者中发现了精神分裂症 死亡者(23%)仅限于全身性萎缩、神经胶质增生和神经元丢失--不涉及特定的 致病机理在这一人群中,减少NFT和NP负担的预防策略 在不影响其他进程的情况下,可能会对公共卫生产生适度的影响。我们的研究结果 这表明,高效的预防计划可能需要同时针对两个或两个以上的人 更多的潜在过程。采用神经病理学病变作为终点的分析如下: 进行的努力,以确定特定的潜在致病过程的特定风险因素, 为预防迈出了重要的第一步。除了增加尸检外, 继续将支持致力于(1)微血管缺血性疾病的研究,(2) 微梗死的分布和密度与阿尔茨海默病病变之间的关系,(3) Willis动脉环结构特征与脑内病变的关系 实质,和(4)确定负责脑的主要潜在致病过程 萎缩和神经胶质增生,并确定相应的危险因素。

项目成果

期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Impairments in activities of daily living in older Japanese men in hawaii and Japan.
  • DOI:
    10.4061/2011/324592
  • 发表时间:
    2011-01-01
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Abbott, Robert D;Kadota, Aya;Ueshima, Hirotsugu
  • 通讯作者:
    Ueshima, Hirotsugu
Association of brain heptachlor epoxide and other organochlorine compounds with lewy pathology.
脑环氧化物七氯和其他有机氯化合物与路易病理学的关联。
Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study.
  • DOI:
    10.1002/ana.22520
  • 发表时间:
    2011-11
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    Launer, Lenore J.;Hughes, Timothy M.;White, Lon R.
  • 通讯作者:
    White, Lon R.
Change in blood pressure and incident dementia: a 32-year prospective study.
  • DOI:
    10.1161/hypertensionaha.109.128744
  • 发表时间:
    2009-08
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Stewart R;Xue QL;Masaki K;Petrovitch H;Ross GW;White LR;Launer LJ
  • 通讯作者:
    Launer LJ
Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.
  • DOI:
    10.1002/mds.25144
  • 发表时间:
    2012-09-15
  • 期刊:
  • 影响因子:
    8.6
  • 作者:
    Ross, G. Webster;Duda, John E.;Abbott, Robert D.;Pellizzari, Edo;Petrovitch, Helen;Miller, Diane B.;O'Callaghan, James P.;Tanner, Caroline M.;Noorigian, Joseph V.;Masaki, Kamal;Launer, Lenore;White, Lon R.
  • 通讯作者:
    White, Lon R.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

LON Ray WHITE其他文献

LON Ray WHITE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('LON Ray WHITE', 18)}}的其他基金

GENERAL ADMINISTRATIVE SUPPORT
一般行政支持
  • 批准号:
    8168064
  • 财政年份:
    2010
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Aging and Dementia-Autopsy Research
衰老和痴呆的流行病学-尸检研究
  • 批准号:
    7906358
  • 财政年份:
    2009
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Aging and Damentia - Autopsy Research
衰老和痴呆的流行病学 - 尸检研究
  • 批准号:
    7812728
  • 财政年份:
    2009
  • 资助金额:
    $ 2.1万
  • 项目类别:
GENERAL ADMINISTRATIVE SUPPORT
一般行政支持
  • 批准号:
    7725229
  • 财政年份:
    2008
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Brain Aging in the Very Old
老年人脑老化的流行病学
  • 批准号:
    7489613
  • 财政年份:
    2007
  • 资助金额:
    $ 2.1万
  • 项目类别:
INBRE EVALUATION
因布雷评估
  • 批准号:
    7610114
  • 财政年份:
    2007
  • 资助金额:
    $ 2.1万
  • 项目类别:
GENERAL ADMINISTRATIVE SUPPORT
一般行政支持
  • 批准号:
    7610115
  • 财政年份:
    2007
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Brain Aging in the Very Old
老年人脑老化的流行病学
  • 批准号:
    6319466
  • 财政年份:
    2001
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Brain Aging in the Very Old
老年人脑老化的流行病学
  • 批准号:
    7603085
  • 财政年份:
    2001
  • 资助金额:
    $ 2.1万
  • 项目类别:
Epidemiology of Brain Aging in the Very Old
老年人脑老化的流行病学
  • 批准号:
    6793645
  • 财政年份:
    2001
  • 资助金额:
    $ 2.1万
  • 项目类别:

相似海外基金

Interplay between Aging and Tubulin Posttranslational Modifications
衰老与微管蛋白翻译后修饰之间的相互作用
  • 批准号:
    24K18114
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The Canadian Brain Health and Cognitive Impairment in Aging Knowledge Mobilization Hub: Sharing Stories of Research
加拿大大脑健康和老龄化认知障碍知识动员中心:分享研究故事
  • 批准号:
    498288
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Operating Grants
EMNANDI: Advanced Characterisation and Aging of Compostable Bioplastics for Automotive Applications
EMNANDI:汽车应用可堆肥生物塑料的高级表征和老化
  • 批准号:
    10089306
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Collaborative R&D
関節リウマチ患者のSuccessful Agingに向けたフレイル予防対策の構築
类风湿性关节炎患者成功老龄化的衰弱预防措施的建立
  • 批准号:
    23K20339
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Baycrest Academy for Research and Education Summer Program in Aging (SPA): Strengthening research competencies, cultivating empathy, building interprofessional networks and skills, and fostering innovation among the next generation of healthcare workers t
Baycrest Academy for Research and Education Summer Program in Aging (SPA):加强研究能力,培养同理心,建立跨专业网络和技能,并促进下一代医疗保健工作者的创新
  • 批准号:
    498310
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Operating Grants
Life course pathways in healthy aging and wellbeing
健康老龄化和福祉的生命历程路径
  • 批准号:
    2740736
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Studentship
I-Corps: Aging in Place with Artificial Intelligence-Powered Augmented Reality
I-Corps:利用人工智能驱动的增强现实实现原地老龄化
  • 批准号:
    2406592
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Standard Grant
NSF PRFB FY 2023: Connecting physiological and cellular aging to individual quality in a long-lived free-living mammal.
NSF PRFB 2023 财年:将生理和细胞衰老与长寿自由生活哺乳动物的个体质量联系起来。
  • 批准号:
    2305890
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Fellowship Award
虚弱高齢者のSuccessful Agingを支える地域課題分析指標と手法の確立
建立区域问题分析指标和方法,支持体弱老年人成功老龄化
  • 批准号:
    23K20355
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
「ケア期間」に着目したbiological aging指標の開発
开发聚焦“护理期”的生物衰老指数
  • 批准号:
    23K24782
  • 财政年份:
    2024
  • 资助金额:
    $ 2.1万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了