Morphological and functional Musculo-Skeletal Imaging

描述(由申请人提供)：针对PAR-04-023，来自加州大学旧金山分校(UCSF)、加州大学伯克利分校(UCB)、马萨诸塞州总医院(MGH)和工业(通用电气，GE)的参与者提议与之竞争地续签生物工程研究伙伴关系(BRP)，重点是对疾病和健康中肌肉骨骼系统的形态和功能进行系统研究。我们假设，高场强(3特斯塔和7特斯拉)、高分辨率、快速磁共振结合定量组织评估，将显著影响肌肉骨骼退化和修复过程的临床评估，跨越一系列尺度，从组织到整个器官。这一合作伙伴关系的长期愿景是了解形态、功能和临床症状之间的联系，特别关注骨质疏松症、骨关节炎和退行性椎间盘疾病。具体目标是：目的一：开发用于体外组织定征的多模式成像工具，包括微型计算机断层扫描、傅立叶变换红外成像，用于定征骨、软骨、椎间盘。目的II：建立优化的3特斯拉并行成像的线圈、脉冲序列和重建算法，用于骨、软骨和椎间盘的高分辨率成像。目的：建立7特斯拉条件下骨小梁、软骨和椎间盘的定量磁共振成像。目的：建立优化的3T和7T磁共振成像技术，用于追踪氧化铁标记的间充质干细胞在关节盘和软骨修复中的作用。加州大学旧金山分校的马琼达尔博士将担任BRP的PI，并将得到科学和临床咨询委员会的协助。她将与通用电气的凯利博士和韩博士，以及加州大学旧金山分校的林克博士(临床相关)一起，重点介绍高场肌肉骨骼成像的技术发展。劳伦斯·沃尔德博士将担任MGH的合伙人。来自加州大学旧金山分校WJ 11的Vigneron博士担任加州大学旧金山分校线圈开发和测试的项目负责人。Nelson博士将在研究的图像分析和处理方面与PI密切合作。该项目将涉及来自放射科、整形外科、生物工程专业的学生和博士后研究人员的临床教师，他们都专注于推进骨质疏松症、骨关节炎和下腰痛等肌肉骨骼疾病的临床评估。

DESCRIPTION (provided by applicant): In response to PAR-04-023, participants from the University of California San Francisco (UCSF), University of California Berkeley (UCB), Massachusetts general Hospital (MGH) and industry (GeneralElectric, GE) propose a competing renewal of a Bioengineering Research Partnership (BRP) focused on the systematic study of the morphology and function of the musculoskeletal system in disease and health. We hypothesize that high field (3 Testa and 7 Tesla), high resolution, fast MR combined with quantitative tissue assessment, would significantly impact the clinical assessment of musculo-skeletal degeneration and reparative processes, spanning a range of scales, from the tissue to the whole organ. The long- term vision of this partnership is to understand the link between morphology, function and clinical symptoms, with a specific focus on osteoporosis, osteo-arthritis, degenerative disc disease. The specific aims are: Aim I: To develop multi-modality imaging tools for in-vitro tissue characterization, including micro-computed tomography, Fourier transform Infra-red imaging for use in characterizing bone, cartilage, intervertebral disc. Aim II: To develop coils, pulse sequences and reconstruction algorithms for optimized parallel imaging at 3 Tesla for high resolution imaging of bone, cartilage, and intervertebral disc. Aim III: To develop quantitative MR imaging of trabecular bone, cartilage and intervertebral disc at 7 Tesla. Aim IV: To develop optimized MR imaging techniques at 3 Tesla and 7 Tesla in rodent models of disc and cartilage degeneration for tracking of iron oxide labeled mesenchymal stem cells in cartilage and disc repair. Dr. Majumdar from UCSF will serve as the PI of the BRP, and will be assisted by a Scientific and Clinical Advisory board. She will focus on the technical developments for musculo-skeletal imaging at high field with Dr. Kelley and Han from GE, and Link from UCSF (for clinical relevance). Dr. Lawrence Wald will serve as the partner from MGH. Dr. Vigneron from UCSF wj 11 serve as the project leader for coil development and testing at UCSF. Dr. Nelson will work closely with the PI in image analysis and processing aspects of the study. The project will involve clinical faculty from Departments of Radiology, Orthopedic Surgery, Bioengineering students and post-doctoral researchers, all focused on advancing clinical evaluation of musculo-skeletal diseases such as osteoporosis, osteo-arthritis and lower back pain.