The Epidemiology of Obesity Metabolism in the Menopausal Transition

绝经过渡期肥胖代谢的流行病学

• 批准号: 7316119
• 负责人: Rachel P Wildman
• 金额: $ 75.43万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7316119
• 关键词: Address; Age; Aging; All Sites; Androgens; Biochemical Markers; Biology; Blood Pressure; Body Composition; Body Size; Cardiovascular system; Chronic Disease; Classification; Communities; Complex; Cross-Sectional Studies; Data; Databases; Development; Dyslipidemias; Elderly; Endocrine; Energy Metabolism; Epidemic; Epidemiology; Evaluation; Follicle Stimulating Hormone; Funding; Goals; Gonadal Steroid Hormones; Health Expenditures; High Blood Pressure; Individual; Inflammation; Insulin Resistance; Leptin; Level of Evidence; Lipids; Measurement; Measures; Menopausal Status; Menopause; Menstruation; Metabolic; Metabolism; Monitor; Non obese; Obesity; Ovarian; Perimenopause; Phase; Pilot Projects; Plant Roots; Play; Population; Postmenopause; Premenopause; Process; Public Health; Regulation; Relative (related person); Reporting; Research; Research Personnel; Resources; Risk Factors; Risk Marker; Role; Sampling; Sampling Studies; Serum; Site; Specimen; Staging; Visit; Weight; Woman; Women' s Health; adiponectin; aged; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; experience; follow-up; ghrelin; indexing; obesity treatment; programs; prospective; repository; reproductive hormone; resistin

DESCRIPTION (provided by applicant): This application will characterize the development and longitudinal progression of cardiovascular disease (CVD) risk factors in relation to biochemical markers of obesity metabolism in a multi-ethnic population of women, considering the 10-year period of the menopausal transition. In the process, the study will provide unique and needed information to address the public health obesity crisis at the age threshold for expression of chronic diseases of the elderly. This study will be conducted using existing data and Repository specimen resources of SWAN (Study of Women's Health Across the Nation), a prospective, multi-ethnic, multi-site evaluation of the menopausal transition in 3,302 women (aged 42-52 years at the 1996/97 baseline). The specific aims are 1) to characterize the cross-sectional and longitudinal relationships between obesity-related metabolites and CVD risk markers, including the clustering of CVD risk markers; 2) to determine the relative contributions of chronological and ovarian aging (e.g., menopause stages and reproductive hormones) to obesity-related markers levels and their changes (ghrelin and the adipocytokines adiponectin, resistin, and leptin); and 3) characterize if and when measures of ovarian aging modify relationships between obesity markers and CVD risk markers. Thus, this will be the first examination of the interrelationships between biochemical markers of obesity metabolism, ovarian aging, and CVD risk. These proposed aims will be addressed using existing SWAN data and SWAN Repository specimens from 1) all women present at the 6th annual SWAN follow-up visit (for cross-sectional analyses), and 2) all women who have experienced their final menstrual period and have specimen and covariate data within each of the 4 phases of the menopausal transition (for longitudinal analyses). Much remains unknown regarding the mechanisms which underlie the CVD risk associated with obesity, especially given that not all obese individuals possess the associated metabolic derangements that place them at greater CVD risk. A systematic examination of the effects of ovarian aging on obesity metabolism in relation to CVD risk markers is needed to better distinguish between those who will likely suffer obesity-associated cardiovascular complications and those who will not.

描述(申请人提供)：这项申请将表征心血管疾病(CVD)危险因素的发展和纵向进展，与肥胖代谢的生化标记物有关的多种族女性人口，考虑到更年期的10年。在此过程中，这项研究将提供独特和所需的信息，以解决老年人慢性病表现的年龄门槛处的公共健康肥胖危机。这项研究将使用SWAN(全国妇女健康研究)的现有数据和资料库标本资源进行，这是一项对3302名妇女(1996/97年基线年龄为42-52岁)绝经过渡的前瞻性、多种族、多地点评估。其具体目的是1)描述肥胖相关代谢物和心血管疾病风险标记物之间的横向和纵向关系，包括心血管疾病风险标记物的聚集；2)确定时间顺序和卵巢老化(例如绝经阶段和生殖激素)对肥胖相关标记物水平及其变化的相对贡献(Ghrelin和脂肪细胞因子脂联素、抵抗素和瘦素)；以及3)表征卵巢老化措施是否以及何时改变肥胖标记物和心血管疾病危险标记物之间的关系。因此，这将是第一次检查肥胖代谢、卵巢老化和心血管疾病风险的生化标记物之间的相互关系。这些拟议的目标将使用现有的SWAN数据和SWAN资料库标本来实现，这些样本来自1)参加第六次年度SWAN随访的所有妇女(用于横断面分析)，以及2)所有经历了最后一个月经时期并拥有更年期4个阶段中每一个阶段的标本和协变量数据(用于纵向分析)的所有妇女。与肥胖相关的心血管疾病风险的机制尚不清楚，特别是考虑到并不是所有的肥胖个体都有相关的代谢紊乱，这些代谢紊乱使他们处于更大的心血管疾病风险中。需要对卵巢老化对肥胖代谢的影响与心血管疾病风险标记物的关系进行系统的检查，以更好地区分哪些人可能会遭受肥胖相关的心血管并发症，哪些人不会。