The Epidemiology of Obesity Metabolism in the Menopausal Transition

绝经过渡期肥胖代谢的流行病学

• 批准号: 7483715
• 负责人: Rachel P Wildman
• 金额: $ 73.76万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483715
• 关键词: Address; Age; Aging; All Sites; Androgens; Biochemical Markers; Biology; Blood Pressure; Body Composition; Body Size; Cardiovascular system; Chronic Disease; Classification; Communities; Complex; Cross-Sectional Studies; Data; Databases; Development; Dyslipidemias; Elderly; Endocrine; Energy Metabolism; Epidemic; Epidemiology; Evaluation; Follicle Stimulating Hormone; Funding; Goals; Gonadal Steroid Hormones; Health Expenditures; High Blood Pressure; Individual; Inflammation; Insulin Resistance; Leptin; Level of Evidence; Lipids; Measurement; Measures; Menopausal Status; Menopause; Menstruation; Metabolic; Metabolism; Monitor; Non obese; Obesity; Ovarian; Perimenopause; Phase; Pilot Projects; Plant Roots; Play; Population; Postmenopause; Premenopause; Process; Public Health; Regulation; Relative (related person); Reporting; Research; Research Personnel; Resources; Risk Factors; Risk Marker; Role; Sampling; Sampling Studies; Serum; Site; Specimen; Staging; Visit; Weight; Woman; Women' s Health; adiponectin; aged; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; experience; follow-up; ghrelin; indexing; obesity treatment; programs; prospective; repository; reproductive hormone; resistin

DESCRIPTION (provided by applicant): This application will characterize the development and longitudinal progression of cardiovascular disease (CVD) risk factors in relation to biochemical markers of obesity metabolism in a multi-ethnic population of women, considering the 10-year period of the menopausal transition. In the process, the study will provide unique and needed information to address the public health obesity crisis at the age threshold for expression of chronic diseases of the elderly. This study will be conducted using existing data and Repository specimen resources of SWAN (Study of Women's Health Across the Nation), a prospective, multi-ethnic, multi-site evaluation of the menopausal transition in 3,302 women (aged 42-52 years at the 1996/97 baseline). The specific aims are 1) to characterize the cross-sectional and longitudinal relationships between obesity-related metabolites and CVD risk markers, including the clustering of CVD risk markers; 2) to determine the relative contributions of chronological and ovarian aging (e.g., menopause stages and reproductive hormones) to obesity-related markers levels and their changes (ghrelin and the adipocytokines adiponectin, resistin, and leptin); and 3) characterize if and when measures of ovarian aging modify relationships between obesity markers and CVD risk markers. Thus, this will be the first examination of the interrelationships between biochemical markers of obesity metabolism, ovarian aging, and CVD risk. These proposed aims will be addressed using existing SWAN data and SWAN Repository specimens from 1) all women present at the 6th annual SWAN follow-up visit (for cross-sectional analyses), and 2) all women who have experienced their final menstrual period and have specimen and covariate data within each of the 4 phases of the menopausal transition (for longitudinal analyses). Much remains unknown regarding the mechanisms which underlie the CVD risk associated with obesity, especially given that not all obese individuals possess the associated metabolic derangements that place them at greater CVD risk. A systematic examination of the effects of ovarian aging on obesity metabolism in relation to CVD risk markers is needed to better distinguish between those who will likely suffer obesity-associated cardiovascular complications and those who will not.

描述（由申请方提供）：本申请将描述多种族女性人群中与肥胖代谢生化标志物相关的心血管疾病（CVD）风险因素的发展和纵向进展，考虑到绝经过渡期为10年。在此过程中，该研究将提供独特且所需的信息，以解决老年人慢性病表现年龄阈值的公共卫生肥胖危机。本研究将使用现有数据和SWAN（全国妇女健康研究）的储存库样本资源进行，SWAN是对3，302名妇女（1996/97年基线时年龄为42-52岁）的绝经过渡期进行的前瞻性、多种族、多地点评价。具体目的是1）表征肥胖相关代谢物和CVD风险标志物之间的横截面和纵向关系，包括CVD风险标志物的聚类; 2）确定时间和卵巢衰老的相对贡献（例如，绝经阶段和生殖激素）与肥胖相关的标志物水平及其变化（生长激素释放肽和脂肪细胞因子脂联素、瘦素和促性腺激素释放肽）的关系;和3）表征卵巢衰老的测量是否以及何时改变肥胖标志物和CVD风险标志物之间的关系。因此，这将是第一次检查肥胖代谢，卵巢老化和CVD风险的生化标志物之间的相互关系。这些拟定目标将使用现有SWAN数据和SWAN储存库样本来解决，这些样本来自1）第6次年度SWAN随访访视时的所有女性（用于横断面分析），以及2）经历末次月经期并在绝经过渡的4个阶段中的每个阶段内具有样本和协变量数据的所有女性（用于纵向分析）。与肥胖相关的心血管疾病风险的机制仍然未知，特别是考虑到并非所有肥胖个体都具有使其处于更高心血管疾病风险的相关代谢紊乱。需要系统检查卵巢老化对肥胖代谢与CVD风险标志物的影响，以更好地区分那些可能患有肥胖相关心血管并发症的人和那些不会的人。