Obesity subtypes, adiponectin and incident stroke among postmenopausal women

绝经后女性的肥胖亚型、脂联素和中风事件

• 批准号: 7360808
• 负责人: Rachel P Wildman
• 金额: $ 8.33万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7360808
• 关键词: Address; Adipocytes; Adipose tissue; Affect; African; African American; Area; Biological Markers; Body Weight decreased; Cardiovascular system; Case-Control Studies; Caucasians; Caucasoid Race; Cerebrovascular Disorders; Clinical; Coronary Arteriosclerosis; Data; Development; Dyslipidemias; Endocrine; Epidemic; Ethnic Origin; Evaluation; Exhibits; Fatty acid glycerol esters; Frequencies; Funding; Future; Goals; Health Expenditures; High Prevalence; Hormones; Hypertension; Incidence; Individual; Inflammation; Insulin Resistance; Intervention; Ischemic Stroke; Metabolic; Metabolism; Molecular Weight; Monitor; Non obese; Obesity; Observational Study; Phenotype; Physiological Processes; Postmenopause; Process; Public Health; Race; Rate; Reaction; Refractory; Research; Risk; Risk Factors; Risk Reduction; Role; Specimen; Stroke; Stroke prevention; Woman; Women' s Health; abstracting; adiponectin; base; cardiovascular disorder risk; cardiovascular risk factor; caucasian American; cerebrovascular; cohort; cytokine; disability; lipid metabolism; obesity treatment; racial difference; response; success; tool

DESCRIPTION (provided by applicant): ABSTRACT: Obesity has been shown to confer increased risk of coronary artery disease and stroke. However, recent data suggest that there are some obese persons who appear to be metabolically healthy. These individuals may not be at any increased risk of cardiovascular disease and may, in fact, have adverse metabolic reactions to weight loss treatments. Whether obesity subtypes are at differential risk of cerebrovascular disease and whether this risk is associated with cytokines from adipocytes is not known. This application will examine whether obesity subtypes exhibit differential risk for ischemic stroke, and consider mechanisms underlying these differential risks including levels of high-molecular weight (HMW) adiponectin. Data from the Women's Health Initiative Observational Cohort (WHI-OS) NINDS-funded nested stroke case-control study, Hormones and Biomarkers Predicting Stroke (HaBPS) will be used. The specific aims are: 1.) To examine the association between baseline obesity subtypes (obese with metabolic abnormalities, obese but metabolically healthy, non-obese but with metabolic abnormalities, non-obese and metabolically healthy) and ischemic stroke risk, 2.) To examine the association between HMW adiponectin levels and obesity subtypes and determine whether adiponectin levels may partially explain any increased stroke risk associated with metabolic obesity, and 3.) To examine racial differences in obesity subtypes and HMW adiponectin levels, and the extent to which adiponectin levels explain any racial differences in obesity subtypes. Examination of the stroke risk associated with obesity subtypes, as well as the specific adipose endocrine factors which may underlie the differential risk will provide information vital to distinguishing between women who will likely suffer obesity-associated cerebrovascular complications, such as stroke, and women who will not. As the obesity epidemic continues to grow and health care expenditures increase, an understanding of these relationships will be critical to further development of anti-obesity therapies, and targeting of those therapies to the individuals who most need it and in whom it will be most effective. NARRATIVE: Given the high rate of stroke and subsequent disability in the U.S., and the high prevalence of obesity, this study will provide information essential to stroke prevention, the development of obesity treatment strategies, and evaluation into their appropriate indications. Should obesity phenotypes be found to be at differential stroke risk and the causal factors underlying such risk discovered, further research could examine these factors not only as future targets of intervention, but also as clinical tools for monitoring the success of anti-obesity treatments. Therefore, this application could have a significant impact on stroke prevention as it relates to appropriate treatment indications for obesity.

摘要：肥胖已被证明会增加冠状动脉疾病和中风的风险。然而，最近的数据表明，有些肥胖者的新陈代谢似乎是健康的。这些人患心血管疾病的风险可能不会增加，事实上，他们可能对减肥治疗有不良的代谢反应。肥胖亚型是否存在脑血管疾病的不同风险，以及这种风险是否与脂肪细胞的细胞因子有关，目前尚不清楚。该应用程序将检查肥胖亚型是否表现出缺血性卒中的不同风险，并考虑这些差异风险的机制，包括高分子量（HMW）脂联素水平。数据来自妇女健康倡议观察队列（WHI-OS） ninds资助的嵌套卒中病例对照研究，激素和生物标志物预测卒中（HaBPS）将被使用。具体目标是：1)研究基线肥胖亚型（肥胖伴代谢异常、肥胖但代谢健康、非肥胖但代谢异常、非肥胖但代谢健康）与缺血性卒中风险之间的关系。2 .检查HMW脂联素水平与肥胖亚型之间的关系，并确定脂联素水平是否可以部分解释与代谢性肥胖相关的卒中风险增加；研究肥胖亚型和HMW脂联素水平的种族差异，以及脂联素水平在多大程度上解释肥胖亚型的种族差异。检查与肥胖亚型相关的中风风险，以及可能导致不同风险的特定脂肪内分泌因素，将为区分可能遭受肥胖相关脑血管并发症（如中风）的女性和不会遭受肥胖相关脑血管并发症的女性提供重要信息。随着肥胖流行病的持续增长和医疗保健支出的增加，对这些关系的理解将对进一步发展抗肥胖疗法至关重要，并将这些疗法针对最需要它的个体，并对其最有效。