Low-Cost Device for Digital Retinal Imaging

我们计划优化一种低成本、使用简单、非侵入性的成像设备，即激光扫描数字成像仪。 摄像机（LSDC）。LSDC具有激光扫描照明，以增加眼底相机的对比度， 将拥有消费级数码相机的用户界面。LSDC用作筛选设备， 提供图像存储和数据库，供眼睛护理提供者存储和转发使用。它不散瞳 对病人来说很舒适。我们将使用最长的波长，提供可接受的对比度， 532和850 nm，从而最大限度地减少由于眼底暗和白内障引起的问题。我们的目标是让LSDC 有一个前期，一次性成本< 10%的高端成像设备，但识别患者的灵敏度， 风险是主要标准。 我们将研究早期发现的关键特征，加上更先进的可能在 农村和城市得不到充分服务的人。沿着微动脉瘤和出血，我们将研究黄斑 水肿，包括囊样黄斑水肿;视网膜血管变化和新生血管形成;硬性渗出物; 通过糖尿病性白内障可视化;黄斑牵引;视网膜脱离;和虹膜新生血管。 我们计划5个具体目标：1）建立一个原型LSDC成像40度的视网膜，2）进行实验室 使用高端激光扫描设备进行测试，以确定舒适的近红外光源是否可以产生 可接受的图像质量，而不是典型的不协调明亮的较短波长， 瞳孔，3）探索使用近红外成像在病理特征中实现的灵敏度和对比度 技术，4）优化LSDC的光学设计和波长选择，以及5）执行盲检测。 在实验室中用原型LSDC进行分级研究。 我们的目标是减少健康差距和由此导致的糖尿病视网膜病变导致的视力丧失。我们 正在开发一种筛查糖尿病视网膜病变的方法， 使用强光的相机。其目的是制造一种像消费者数字一样工作的仪器 相机这两个因素可能有助于接触更多的患者。我们将研究其关键特征 被认为是必要的早期检测分级，也更严重的损害，这是典型的 在农村和城市发现得晚，服务不足。

We plan to optimize a low cost, simple-to use, non-invasive imaging device, the Laser Scanning Digital Camera (LSDC). The LSDC has laser scanning illumination to increase contrast over a fundus camera and will have the user interface of a consumer-level digital camera. The LSDC serves as a screening device that provides image storage and a database for store and forward use by eye care providers. It is non-mydriatic and comfortable for patients. We will use the longest wavelength that provides acceptable contrast between 532 and 850 nm, thereby minimizing problems due to dark fundi and cataract. Our goal is for the LSDC to have an up front, one-time cost < 10% of high end imaging devices, but sensitivity of identifying patients at risk is the main criterion. We will investigate the key features for early detection with grading, plus the more advanced ones likely in the rural and urban underserved. Along with microaneurysms and hemhorrages, we will investigate macular edema including cystoid macular edema; retinal vascular changes and neovascularization; hard exudates; visualization through diabetic cataract; macular traction; retinal detachment; and iris neovascularization. We plan 5 Specific Aims: 1) build a prototype LSDC that images 40 deg of retina, 2) perform laboratory tests with a high end laser scanning device to determine if a comfortable, near IR light source can produce acceptable image quality instead of the typical uncomformably bright shorter wavelegnths that constrict the pupil, 3) explore what sensitvities and contrasts are achieved in pathological features using near IR imaging techniques, 4) optimize the optical design and wavelength selection of the LSDC, and 5) perform a blind grading study with prototype LSDC in the laboratory. Our goal is to reduce health disparities and the resulting loss of vision due to diabetic retinopathy. We are developing a method of screening for diabetic retinopathy that is far more comfortable than present nonmydriatic cameras that use bright light. The aim is to make an instrument that works like a consumer digital camera. Both of these factors may help reach more patients. We will investigate the key features considered necessary for early detection grading, and also more the serious damage that is typically discovered late in the rural and urban underserved.