Low-Cost Device for Digital Retinal Imaging

用于数字视网膜成像的低成本设备

• 批准号: 7833292
• 负责人: ANN E ELSNER
• 金额: $ 37.95万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-05 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7833292
• 关键词: Adult; Age; Anterior; Area; Beds; Blindness; Blood Vessels; Blurred vision; Caring; Cataract; Clinical Research; Complications of Diabetes Mellitus; Computers; Computing Methodologies; Contracts; Cystoid Macular Edema; Data; Databases; Detection; Devices; Diabetes Mellitus; Diabetic Retinopathy; Diagnostic Imaging; Dilatation - action; Disadvantaged; Early Diagnosis; Edema; Electronics; Elements; Engineering; Ethnic group; Exudate; Eye; Eye Color; Eyeglasses; Fiber; Fixed Pupils; Funding; Fundus; Gender; Glass; Goals; Height; Housing; Hybrids; Image; Imagery; Imaging Device; Imaging Techniques; Individual; Investigation; Iris; Knowledge; Lasers; Lead; Lesion; Light; Lighting; Maps; Measurement; Measures; Mechanics; Methods; Microaneurysm; Microscopy; Minority; Miosis disorder; Morphologic artifacts; Motor; Mydriasis; Mydriatics; National Institute of Biomedical Imaging and Bioengineering; Ophthalmoscopes; Optics; Outcome; Patients; Performance; Photography; Pigmentation physiologic function; Positioning Attribute; Price; Production; Provider; Pupil; Quality Control; Reading; Records Controls; Recovery; Refractive Errors; Reproducibility; Research; Resolution; Retina; Retinal; Retinal Detachment; Retinal Diseases; Risk; Scanning; Screening procedure; Series; Severities; Shapes; Signal Transduction; Solutions; Source; Specialist; Staging; Structure; Students; Surface; Surrogate Markers; System; Techniques; Technology; Testing; Time; Traction; Training; United States National Institutes of Health; Variant; Vision; Work; base; bioimaging; cost; cost effective; data acquisition; design; detector; diabetic; diabetic cataract; diabetic patient; digital; digital imaging; experience; field study; flexibility; health disparity; improved; instrument; instrumentation; laptop; light scattering; macula; macular edema; medical specialties; minority subjects; neovascularization; new technology; novel; novel strategies; older patient; optical communication; parent grant; public health relevance; relating to nervous system; sensor; voltage

DESCRIPTION (provided by applicant): This proposal will accelerate the tempo of scientific research of NIBIB RO1 EB002346, "Low-Cost Device for Digital Retinal Imaging," by means of Notice Number (NOT-OD-09-058) under the Notice Title: NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications. We are enhancing our novel design for a low cost Laser Scanning Digital Camera (LSDC), for use in diabetic retinopathy screening without pupil dilatation, by adding a motor and sensor on our focusing state that will provide the potential for autofocus, which will assist operators with little experience. Reducing the cost of operators is important in the per use cost of the device, allowing screening to be accomplished in a more cost effective manner. To reach the underserved, the LSDC does not require pupil dilation and yet provides a high contrast, digital image. The LSDC is designed to work well with small pupils and comfortable light level, producing continuous images to assist the operator during data acquisition. The use of near Infrared illumination provides this high contrast in all eye colors, so that minority subjects who have dark eyes still readily imaged with comfortable light levels. The proposed new autofocus feature automatically adds the potential for the LSDC serving as an autorefractor, a cataract detection device, and a retinal topographer to detect macular edema in an objective manner. We will test and optimize this device in subjects with a wide range of refractive errors and eye color, patients with cataract, and diabetic patients with retinopathy including macular edema. We will compare performance with that of age-matched and gender-matched normal control subjects. We will also compare the results of the new technology to that of high end devices, such as the IOL Master, spectral domain OCT, and wavefront aberrations. Our main goal is to provide high contrast retinal images in patients of all ethnic groups and including older patients for purposes of detection of diabetic retinopathy. The added functionality leads to greater energy efficiency because several functions can be accomplished in one instrument, saving on power, part count, footprint, and patient chair time. The data produced by this instrument will also provide a wealth of information to be used in the training of students. PUBLIC HEALTH RELEVANCE: We will modify our low cost retinal imaging device, the Laser Scanning Digital Camera, to investigate a low cost method to improve operator focus, measure refraction, investigate eye shape, quantify cataract, and quantify the severity of macular edema. Once developed, increased the functionality requires minimal added cost, providing energy efficiency by combining functions into a single device.

描述（由申请人提供）：该提案将通过公告编号（NOT-OD-09-058）加快 NIBIB RO1 EB002346“数字视网膜成像低成本设备”的科学研究节奏，公告标题为：NIH 宣布恢复法案基金可用于竞争性修订申请。我们正在增强低成本激光扫描数码相机 (LSDC) 的新颖设计，用于在无需瞳孔扩张的情况下进行糖尿病视网膜病变筛查，通过在我们的聚焦状态上添加电机和传感器，这将提供自动对焦的潜力，这将帮助缺乏经验的操作员。降低操作员成本对于设备的每次使用成本非常重要，从而能够以更具成本效益的方式完成筛查。为了惠及服务不足的人群，LSDC 不需要瞳孔扩张，但可以提供高对比度的数字图像。 LSDC 专为在小瞳孔和舒适的光线水平下良好工作而设计，可生成连续图像以在数据采集过程中为操作员提供帮助。近红外照明的使用为所有眼睛颜色提供了这种高对比度，因此少数黑眼睛的拍摄对象仍然可以在舒适的光线水平下轻松成像。所提出的新自动对焦功能自动增加了 LSDC 作为自动验光仪、白内障检测设备和视网膜地形图仪的潜力，以客观的方式检测黄斑水肿。我们将在患有各种屈光不正和眼睛颜色的受试者、白内障患者以及患有视网膜病变（包括黄斑水肿）的糖尿病患者中测试和优化该设备。我们将把表现与年龄匹配和性别匹配的正常对照受试者进行比较。我们还将把新技术的结果与 IOL Master、频域 OCT 和波前像差等高端设备的结果进行比较。我们的主要目标是为所有种族的患者（包括老年患者）提供高对比度视网膜图像，以检测糖尿病视网膜病变。增加的功能可以提高能源效率，因为多种功能可以在一台仪器中完成，从而节省电力、零件数量、占地面积和患者就诊时间。该仪器产生的数据还将提供丰富的信息用于学生的培训。 公共健康相关性：我们将修改我们的低成本视网膜成像设备——激光扫描数码相机，以研究一种低成本方法来提高操作员注意力、测量屈光度、研究眼睛形状、量化白内障和量化黄斑水肿的严重程度。一旦开发完成，增加的功能只需最少的增加成本，通过将功能组合到单个设备中来提供能源效率。