Impact of feeding on brain response to food stimuli in lean and obese subjects

描述（由申请方提供）：人类食欲研究以前仅限于使用视觉模拟量表和食物摄入量测量。随着新的大脑成像技术的使用，我们现在可以检查大脑对体内食物刺激的反应。我们最近开发并测试了一种功能性磁共振成像（fMRI）协议，以研究大脑对食物刺激的反应。我们建议使用这个协议来检查和比较大脑反应的食物刺激瘦和肥胖的受试者在禁食和进食状态。12名瘦女性和12名肥胖女性将在禁食一夜和标准餐后接受扫描。功能磁共振成像方案将由区组设计组成，其中受试者在观看真实的食物和非食物物品时以及在触摸食物和非食物物品时将被扫描。在空腹fMRI方案之后，瘦和肥胖受试者将消耗液体膳食，为他们提供估计能量需求的35%。用餐将在20分钟内完成，随后的fMRI扫描将在用餐后30分钟进行。那些在视觉上和视觉上都被食物激活，但在视觉上和视觉上都没有被非食物激活的大脑区域将被认为是由于食物而被激活的。这些研究将使我们能够根据个体的体重和进食状况来检查个体大脑反应的差异。如果大脑对食物刺激的反应在瘦个体和肥胖个体之间是不同的，那么长期目标是确定肥胖个体对食物刺激的大脑反应是否可以通过减肥来改变，并检查健康瘦个体和肥胖个体之间对食物刺激的大脑反应是否存在差异。这项研究的结果将有助于为研究人类全脑水平对食物的综合反应奠定基础，并为一系列创新的实验范式奠定基础。

DESCRIPTION (provided by applicant): The study of appetite in humans has previously been confined to the use of visual analog scales and food intake measurements. With the use of new brain imaging techniques, we can now examine brain activity in response to food stimuli in vivo. We have recently developed and tested a functional magnetic resonance imaging (fMRI) protocol to study brain responses to food stimuli. We propose to use this protocol to examine and compare brain responses to food stimuli in lean and obese subjects in the fasted and fed states. Twelve lean and 12 obese women will be scanned after an overnight fast and after a standard meal. The fMRI protocol will consist of a block design in which subjects will be scanned when viewing real foods and non- food items and when touching foods and non-food items. After the fasting fMRI protocol, lean and obese subjects will consume a liquid meal providing them with 35% of their estimated energy requirements. The meal will be consumed within a 20-minute period and the subsequent fMRI scan will be taken 30 minutes following meal consumption. Brain regions that are more robustly activated both visually and tactilely with food but not also activated visually and tactilely with non-foods will be considered to be activated due to foods. These studies will allow us to examine differences in individual's brain responses based on their body weight and feeding status. If brain responses to food stimuli are different between lean and obese individuals, the long-term goals are to determine whether the brain responses of obese individuals to food stimuli can be modified with weight loss and to examine whether there are differences in brain responses to food stimuli between healthy lean individuals and anorexics. Results of this study will help create the foundation for the study of integrative responses to foods at the whole brain level in humans and will set the stage for a series of innovative experimental paradigms.