IMPACT OF FEEDING ON BRAIN RESPONSE TO FOOD STIMULI IN LEAN AND OBESE SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目标是比较瘦身和肥胖受试者禁食和进食时大脑对食物而不是非食物刺激的反应。这项研究将使我们能够确定在食物刺激下，瘦人和肥胖者之间的大脑活动是否存在差异，这可能是肥胖的原因。12名苗条女性和12名肥胖女性将被招募参加。所有受试者都将接受彻底的筛查程序，以评估他们的精神状态和体内可能存在的任何金属。受试者将在心内科接受两次相隔两周的扫描访问。在两次扫描检查之前，受试者必须处于禁食状态。在扫描仪中，受试者将在每个4-6分钟的几个时间段内随机顺序查看或触摸食物或物体。每个食物或物体将被观看或触摸4个S。在每个时段内，受试者将观看或触摸40-60个食物和物体。这项研究中使用的食物和物品将根据认知度和吸引力进行选择，不会凌乱或具有吸引力。受试者将被要求躺在磁铁中，在整个扫描过程中不移动他们的头。这些程序应该持续大约40-90分钟。在提供食物的情况下，受试者将被要求在15分钟内食用配方餐，并在30分钟后进行扫描。扫描后，受试者将被要求对他们在研究过程中观看和触摸的食物和物体喜欢或不喜欢进行评级。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to compare brain activity in response to food but not non-food stimuli of lean and obese subjects while fasted and fed. This study will allow us to determine whether there are differences in brain activity under stimulation with food between lean and obese individuals that may explain obesity. Twelve lean and twelve obese women will be recruited to participate. All subjects will undergo a thorough screening procedure to evaluate their mental status and possible presence of any metal within their body. Subjects will undergo two scanning visits separated by two weeks at the Department of Cardiology. Prior to both scanning visits the subjects must be in a fasted state. While in the scanner, subjects will view or touch foods or objects in random order within several periods of 4-6 minutes each. Each food or object will be viewed or touched for a period of 4 s. Subjects will view or touch 40-60 foods and objects during each period. Foods and objects used in this study will be selected based on ease of recognition and appeal and will not be messy or magnetic. Subjects will be required to lie in the magnet without moving their head for the total duration of the scanning procedures. These procedures should last approximately 40-90 minutes. On the occasion where a meal will be served, subjects will be asked to consume the formula meal in 15 minutes and scanning will take place 30 minutes later. Following the scans, the subjects will be asked to rate whether they liked or disliked the foods and objects viewed and touched during the study.