IMPACT OF FEEDING ON BRAIN RESPONSE TO FOOD STIMULI IN LEAN AND OBESE SUBJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是比较瘦和肥胖受试者在禁食和进食时对食物刺激而非非食物刺激的大脑活动。这项研究将使我们能够确定瘦和肥胖个体之间在食物刺激下的大脑活动是否存在差异，这可能解释肥胖。将招募12名瘦女性和12名肥胖女性参加。所有受试者将接受全面的筛选程序，以评估其精神状态和体内可能存在的任何金属。受试者将在心脏科接受两次扫描访视，间隔两周。在两次扫描访视之前，受试者必须处于空腹状态。在扫描仪中，受试者将在4-6分钟的时间内以随机顺序查看或触摸食物或物体。每个食物或物体将被观看或触摸4秒。在每个阶段，受试者将看到或触摸40-60种食物和物体。在这项研究中使用的食物和物体将根据易于识别和吸引力来选择，并且不会凌乱或有磁性。要求受试者在整个扫描过程中躺在磁体中，头部不动。这些程序应持续约40-90分钟。在提供膳食的情况下，将要求受试者在15分钟内食用配方餐，并在30分钟后进行扫描。扫描后，受试者将被要求评价他们是否喜欢或不喜欢在研究期间看到和触摸的食物和物体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this study is to compare brain activity in response to food but not non-food stimuli of lean and obese subjects while fasted and fed. This study will allow us to determine whether there are differences in brain activity under stimulation with food between lean and obese individuals that may explain obesity. Twelve lean and twelve obese women will be recruited to participate. All subjects will undergo a thorough screening procedure to evaluate their mental status and possible presence of any metal within their body. Subjects will undergo two scanning visits separated by two weeks at the Department of Cardiology. Prior to both scanning visits the subjects must be in a fasted state. While in the scanner, subjects will view or touch foods or objects in random order within several periods of 4-6 minutes each. Each food or object will be viewed or touched for a period of 4 s. Subjects will view or touch 40-60 foods and objects during each period. Foods and objects used in this study will be selected based on ease of recognition and appeal and will not be messy or magnetic. Subjects will be required to lie in the magnet without moving their head for the total duration of the scanning procedures. These procedures should last approximately 40-90 minutes. On the occasion where a meal will be served, subjects will be asked to consume the formula meal in 15 minutes and scanning will take place 30 minutes later. Following the scans, the subjects will be asked to rate whether they liked or disliked the foods and objects viewed and touched during the study.