Light Measuring Device for Correcting Circadian Disruption

描述（由申请人提供）：该项目的目标是开发一个个人的，独立的昼夜节律光和活动测量设备，以纠正年轻人的睡眠障碍。将双向通信功能集成到设想的系统中，以便远程计算机可以获取实时光线和活动数据，以便进行即时处理，然后根据年轻人所需的任何昼夜节律阶段，生成光（暗）暴露建议。通常，青少年和年轻人在社会可接受的活动/休息时间方面经历了年龄依赖性的睡眠阶段延迟。缺乏对社会可接受的活动/休息时间的娱乐会导致睡眠时间和效率的减少，从而导致一些心理社会压力的症状。一种可以精确测量光/暗暴露以及活动/休息时间的个人设备被设想用于纠正年轻人的昼夜节律干扰问题。根据光照和活动数据预测昼夜节律干扰的回归模型将在受控光照干预研究的基础上开发。为了增强模型，将评估受控光干预后基因表达的变化以及受控光干预后基因表达的变化。基于回归模型和个人光照和活动数据，可以规定一个人体验的特定时间和光照（和黑暗）量，这样她/他就可以进入任何期望的昼夜节律阶段。因此，一种强大的个人测量和通信设备将被开发出来，以减轻年轻人睡眠障碍引起的社会心理压力症状。布朗大学的睡眠实验室将是活动/休息校准研究的地点。除了用于改进模型以预测昼夜节律阶段所需的光照和活动数据外，与个体休息和活动相关的测量，如BMI和睡眠持续时间，将包括在回归模型中，以更好地预测受控光照干预后的昼夜节律相转移。耶鲁大学将测量光照对昼夜基因表达的影响。这里提出的个人设备可以用于任何与昼夜节律睡眠障碍相关的应用，例如时差和轮班工作。

DESCRIPTION (provided by applicant): The goal of this project is to develop a personal, self-contained circadian light and activity measurement device to correct sleep disorders in young adults. Integrated into the envisioned system will be two-way communication capabilities so that real-time light and activity data can be acquired by remote computer for immediate processing and then for generation of a light (and dark) exposure recommendation for any desired circadian phase entrainment desired by the young adult. Commonly adolescents and young adults experience age-dependent delayed sleep phase with respect to socially acceptable activity/rest periods. This lack of entrainment to socially acceptable activity/rest periods can lead to reduced sleep duration and efficiency which in turn can lead to a number of symptoms of psychosocial stress. A personal device that can accurately measure light/dark exposures as well as periods of activity/rest is envisioned for correcting circadian entrainment problems in young adults. A regression model for predicting circadian entrainment from light and activity data will be developed based upon a controlled light intervention study. To augment the model, changes in gene expression following the controlled light intervention will be assessed as well as changes in gene expression following the controlled light intervention. Based upon the regression model and the personal light and activity data, it will be possible to prescribe specific times and amounts of light (and dark) for a person to experience such that she/he can entrain to any desired circadian phase. Thus, a powerful personal measurement and communication device will be developed for alleviating symptoms of psychosocial stress caused by sleep disorders in young adults. The sleep laboratory at Brown University will be the site of the activity/rest calibration studies. In addition to the light and activity data needed for refinement of the model to predict circadian phase, measures related to an individual's rest and activity, such as BMI and sleep duration, will be included in a regression model to better predict circadian phase shifting following a controlled light intervention. Yale University will measure the impact of light exposure on circadian gene expression. The personal device proposed here can be used for any applications associated with circadian sleep disorders, such as jet lag and shift work.