Light Measuring Device for Correcting Circadian Disruption

描述(申请人提供)：这个项目的目标是开发一种个人的，自给自足的昼夜节律光和活动测量设备，以纠正年轻人的睡眠障碍。在设想的系统中集成了双向通信能力，使得远程计算机可以获取实时的光和活动数据，以便立即处理，然后为年轻人所希望的任何所需的昼夜节律相位夹带生成光(和暗)曝光建议。青少年和青壮年通常在社会可接受的活动/休息时间方面经历年龄相关的睡眠延迟阶段。缺乏社会可接受的活动/休息时间可能会导致睡眠时间和效率降低，进而可能导致心理社会压力的一系列症状。人们设想了一种个人设备，可以准确地测量明/暗暴露以及活动/休息时间，以纠正年轻人的昼夜节律缠绕问题。在受控光干预研究的基础上，将开发一个用于根据光和活动数据预测昼夜携带的回归模型。为了加强模型，将评估受控光干预后基因表达的变化以及受控光干预后基因表达的变化。基于回归模型和个人光照和活动数据，将有可能为一个人规定特定的光照(和黑暗)时间和数量，以便她/他可以进入任何所需的昼夜节律阶段。因此，一种强大的个人测量和交流设备将被开发出来，以缓解年轻人睡眠障碍造成的心理社会压力症状。布朗大学的睡眠实验室将是活动/休息校准研究的地点。除了改进模型以预测昼夜节律所需的光和活动数据外，与个人休息和活动相关的指标，如BMI和睡眠持续时间，将被包括在回归模型中，以更好地预测受控光干预后的昼夜相移。耶鲁大学将测量光照对昼夜节律基因表达的影响。这里提出的个人设备可以用于任何与昼夜节律睡眠障碍相关的应用，如时差和倒班工作。

DESCRIPTION (provided by applicant): The goal of this project is to develop a personal, self-contained circadian light and activity measurement device to correct sleep disorders in young adults. Integrated into the envisioned system will be two-way communication capabilities so that real-time light and activity data can be acquired by remote computer for immediate processing and then for generation of a light (and dark) exposure recommendation for any desired circadian phase entrainment desired by the young adult. Commonly adolescents and young adults experience age-dependent delayed sleep phase with respect to socially acceptable activity/rest periods. This lack of entrainment to socially acceptable activity/rest periods can lead to reduced sleep duration and efficiency which in turn can lead to a number of symptoms of psychosocial stress. A personal device that can accurately measure light/dark exposures as well as periods of activity/rest is envisioned for correcting circadian entrainment problems in young adults. A regression model for predicting circadian entrainment from light and activity data will be developed based upon a controlled light intervention study. To augment the model, changes in gene expression following the controlled light intervention will be assessed as well as changes in gene expression following the controlled light intervention. Based upon the regression model and the personal light and activity data, it will be possible to prescribe specific times and amounts of light (and dark) for a person to experience such that she/he can entrain to any desired circadian phase. Thus, a powerful personal measurement and communication device will be developed for alleviating symptoms of psychosocial stress caused by sleep disorders in young adults. The sleep laboratory at Brown University will be the site of the activity/rest calibration studies. In addition to the light and activity data needed for refinement of the model to predict circadian phase, measures related to an individual's rest and activity, such as BMI and sleep duration, will be included in a regression model to better predict circadian phase shifting following a controlled light intervention. Yale University will measure the impact of light exposure on circadian gene expression. The personal device proposed here can be used for any applications associated with circadian sleep disorders, such as jet lag and shift work.