Light Measuring Device for Correcting Circadian Disruption

用于纠正昼夜节律紊乱的光测量装置

• 批准号: 7674844
• 负责人: MARK S REA
• 金额: $ 9.96万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-14 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7674844
• 关键词: Adolescence; Adolescent; Affect; Alcohol or Other Drugs use; Alcohols; Behavior; Behavioral; Caffeine; Calibration; Circadian Rhythms; Communication; Communication Aids for Disabled; Computers; Data; Devices; Disease; Disease regression; Disruption; Distress; Dose; Eating Disorders; Feedback; Gene Expression; Generations; Genes; Genetic Polymorphism; Genetic Predisposition to Disease; Goals; Hormonal; Hour; Hydrocortisone; Immune; Individual; Intervention; Intervention Studies; Jet Lag Syndrome; Laboratories; Lead; Light; Light Exercise; Measurement; Measures; Melatonin; Modeling; Moods; Nicotine; Numbers; Outcome; Pattern; Personal Attribute; Persons; Phase; Population; Process; Psychosocial Stress; Questionnaires; Recommendation; Research Personnel; Rest; Role; Short Waves; Site; Sleep; Sleep Deprivation; Sleep Disorders; Societies; Stress; Symptoms; System; Time; Universities; Wakefulness; Work; addiction; age related; base; day; desire; experience; light treatment; meter; miniaturize; mood regulation; next generation; preference; programs; response; shift work; tool; young adult

DESCRIPTION (provided by applicant): The goal of this project is to develop a personal, self-contained circadian light and activity measurement device to correct sleep disorders in young adults. Integrated into the envisioned system will be two-way communication capabilities so that real-time light and activity data can be acquired by remote computer for immediate processing and then for generation of a light (and dark) exposure recommendation for any desired circadian phase entrainment desired by the young adult. Commonly adolescents and young adults experience age-dependent delayed sleep phase with respect to socially acceptable activity/rest periods. This lack of entrainment to socially acceptable activity/rest periods can lead to reduced sleep duration and efficiency which in turn can lead to a number of symptoms of psychosocial stress. A personal device that can accurately measure light/dark exposures as well as periods of activity/rest is envisioned for correcting circadian entrainment problems in young adults. A regression model for predicting circadian entrainment from light and activity data will be developed based upon a controlled light intervention study. To augment the model, changes in gene expression following the controlled light intervention will be assessed as well as changes in gene expression following the controlled light intervention. Based upon the regression model and the personal light and activity data, it will be possible to prescribe specific times and amounts of light (and dark) for a person to experience such that she/he can entrain to any desired circadian phase. Thus, a powerful personal measurement and communication device will be developed for alleviating symptoms of psychosocial stress caused by sleep disorders in young adults. The sleep laboratory at Brown University will be the site of the activity/rest calibration studies. In addition to the light and activity data needed for refinement of the model to predict circadian phase, measures related to an individual's rest and activity, such as BMI and sleep duration, will be included in a regression model to better predict circadian phase shifting following a controlled light intervention. Yale University will measure the impact of light exposure on circadian gene expression. The personal device proposed here can be used for any applications associated with circadian sleep disorders, such as jet lag and shift work.

描述（由申请人提供）：该项目的目标是开发一种个人的、独立的昼夜节律光和活动测量设备，以纠正年轻人的睡眠障碍。集成到所设想的系统中的将是双向通信能力，使得实时光和活动数据可以由远程计算机获取以用于立即处理，并且然后用于生成针对年轻成人所期望的任何期望的昼夜节律相位夹带的光（和暗）暴露推荐。通常青少年和年轻人经历与社会可接受的活动/休息时间相关的年龄依赖性睡眠期延迟。这种缺乏社会可接受的活动/休息时间的夹带可能导致睡眠持续时间和效率减少，这反过来又可能导致许多心理社会压力的症状。设想一种可以精确测量光/暗暴露以及活动/休息时间段的个人设备，用于校正年轻人的昼夜节律夹带问题。将根据受控光干预研究开发用于根据光和活动数据预测昼夜节律的回归模型。为了增强模型，将评估受控光干预后基因表达的变化以及受控光干预后基因表达的变化。基于回归模型和个人光和活动数据，将有可能规定用于人体验的特定时间和光（和暗）量，使得她/他可以进入任何期望的昼夜节律相位。因此，将开发一种功能强大的个人测量和通信设备，用于减轻年轻人睡眠障碍引起的心理社会压力症状。布朗大学的睡眠实验室将是活动/休息校准研究的地点。除了改进模型以预测昼夜节律相位所需的光和活动数据之外，与个体的休息和活动相关的测量，例如BMI和睡眠持续时间，将被包括在回归模型中，以更好地预测受控光干预后的昼夜节律相移。耶鲁大学将测量光照对昼夜基因表达的影响。这里提出的个人设备可以用于与昼夜睡眠障碍相关联的任何应用，例如时差和轮班工作。