GPER pharmacotherapy in acute stroke

GPER药物治疗急性脑卒中

• 批准号: nhmrc : GNT1085323
• 负责人: A/Pr Thiruma Arumugam
• 金额: $ 84.77万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gper-pharmacotherapy-acute-stroke/1345614
• 关键词: GPER; pharmacotherapy; acute; stroke

This project will test whether activators of a novel estrogen receptor (GPER) can limit brain injury and functional deficits after stroke in mice. Part of the work will evaluate two drugs currently in clinical use for chronic conditions – tamoxifen and estradiol – as potential therapies for use in acute stroke. We will study the therapeutic time window of several drugs over up to a week after stroke, and identify key mechanisms underlying the protection by these GPER drugs.

该项目将测试一种新型雌激素受体（GPER）的激活剂是否可以限制小鼠中风后的脑损伤和功能缺陷。部分工作将评估目前临床上用于慢性疾病的两种药物-他莫昔芬和雌二醇-作为急性中风的潜在治疗方法。我们将研究几种药物在中风后长达一周的治疗时间窗，并确定这些GPER药物保护的关键机制。