Does a Novel Estrogen Receptor Worsen Stroke Outcome?

新型雌激素受体会恶化中风结果吗？

• 批准号: nhmrc : 1010984
• 负责人: A/Pr Thiruma Arumugam
• 金额: $ 35万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-novel-estrogen-stroke-outcome/109542
• 关键词: Does; Novel; Estrogen; Receptor; Worsen

This project will test whether a target protein for estrogen, called GPER, which is found in high levels in the brain, worsens stroke outcome. We will identify the key signalling pathways related to GPER in the brain after stroke and we hope to identify a new type of drug that could be used to treat stroke patients. It is possible that our work could at least partly explain why hormone replacement therapy can increase the risk of worsened outcome after stroke in women.

该项目将测试雌激素的靶蛋白GPER是否会影响中风的结果，GPER在大脑中的含量很高。我们将确定中风后大脑中与GPER相关的关键信号通路，并希望确定一种可用于治疗中风患者的新型药物。我们的工作可能至少部分解释了为什么激素替代疗法会增加女性卒中后结局恶化的风险。