The C-type lectin Mincle exemplifies a new mode of sterile inflammation in cardiovascular disease

C型凝集素Mincle体现了心血管疾病中无菌炎症的新模式

• 批准号: nhmrc : 1057846
• 负责人: A/Pr Thiruma Arumugam
• 金额: $ 40.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/c-type-lectin-cardiovascular-disease/454637
• 关键词: type; lectin; Mincle; exemplifies; new

This project investigates two of the life-changing cardiovascular events that most commonly impact on Australians today; Heart attack and Stroke. These diseases often leave individuals debilitated with a long recovery period, and for many people the event is fatal. We have shown that blocking the action of an immune component, "Mincle", reduces the inflammation associated with stroke, and improves recovery. This project looks at what Mincle does in brain and heart muscle, and why blocking Mincle protects cells from loss of oxygen.

该项目调查了两种改变生活的心血管事件，这些事件最常影响今天的澳大利亚人;心脏病发作和中风。这些疾病往往使个人虚弱，恢复期很长，对许多人来说，这是致命的。我们已经证明，阻断免疫成分“Mincle”的作用，可以减少与中风相关的炎症，并改善恢复。这个项目着眼于Mincle在大脑和心肌中的作用，以及为什么阻断Mincle可以保护细胞免受缺氧的影响。