GPER pharmacotherapy in acute stroke
GPER pharmacotherapy in acute stroke
批准号:
nhmrc : 1085323
负责人:
A/Pr Thiruma Arumugam
金额:
$58.79万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
This project will test whether activators of a novel estrogen receptor (GPER) can limit brain injury and functional deficits after stroke in mice. Part of the work will evaluate two drugs currently in clinical use for chronic conditions – tamoxifen and estradiol – as potential therapies for use in acute stroke. We will study the therapeutic time window of several drugs over up to a week after stroke, and identify key mechanisms underlying the protection by these GPER drugs.
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GPER pharmacotherapy in acute stroke
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批准号:nhmrc : GNT1085323
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项目类别:Project Grants
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资助金额:$84.77万
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财政年份:2015
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Targeting aldosterone receptors in cerebrovascular disease
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批准号:nhmrc : GNT1064686
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项目类别:Project Grants
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资助金额:$82.34万
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财政年份:2014
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负责人:A/Pr Thiruma Arumugam
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依托单位:
The C-type lectin Mincle exemplifies a new mode of sterile inflammation in cardiovascular disease
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批准号:nhmrc : 1057846
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项目类别:Project Grants
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资助金额:$40.62万
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财政年份:2014
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Targeting aldosterone receptors in cerebrovascular disease
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批准号:nhmrc : 1064686
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项目类别:Project Grants
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资助金额:$57.19万
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财政年份:2014
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Mincle has a dual role in tissue loss and inflammation after ischemic injury
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批准号:nhmrc : GNT1057846
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项目类别:Project Grants
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资助金额:$58.69万
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财政年份:2014
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Contribution of Complement C5a to Neuronal Cell Death during Ischemic Stroke
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批准号:nhmrc : 1021413
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项目类别:Project Grants
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资助金额:$30.36万
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财政年份:2012
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Gamma-Secretase inhibitors as novel pharmacological agents to target stroke-induced brain injury
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批准号:nhmrc : 1008048
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项目类别:NHMRC Project Grants
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资助金额:$29.44万
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财政年份:2011
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负责人:A/Pr Thiruma Arumugam
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依托单位:
Does a Novel Estrogen Receptor Worsen Stroke Outcome?
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批准号:nhmrc : 1010984
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项目类别:NHMRC Project Grants
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资助金额:$35.0万
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财政年份:2011
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负责人:A/Pr Thiruma Arumugam
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依托单位:
TNF traffic and secretion in astrocytes and microglial cells: unveilling new targets for ischemic stroke
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批准号:nhmrc : 1005964
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项目类别:NHMRC Project Grants
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资助金额:$39.01万
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财政年份:2011
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负责人:A/Pr Thiruma Arumugam
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依托单位:
海外基金