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GPER pharmacotherapy in acute stroke

GPER pharmacotherapy in acute stroke
GPER药物治疗急性脑卒中
批准号:
nhmrc : 1085323
负责人:
A/Pr Thiruma Arumugam
金额:
$58.79万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31

项目摘要

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中文摘要
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英文摘要
This project will test whether activators of a novel estrogen receptor (GPER) can limit brain injury and functional deficits after stroke in mice. Part of the work will evaluate two drugs currently in clinical use for chronic conditions – tamoxifen and estradiol – as potential therapies for use in acute stroke. We will study the therapeutic time window of several drugs over up to a week after stroke, and identify key mechanisms underlying the protection by these GPER drugs.
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GPER pharmacotherapy in acute stroke
  • 批准号:
    nhmrc : GNT1085323
  • 项目类别:
    Project Grants
  • 资助金额:
    $84.77万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Thiruma Arumugam
  • 依托单位:
Targeting aldosterone receptors in cerebrovascular disease
  • 批准号:
    nhmrc : GNT1064686
  • 项目类别:
    Project Grants
  • 资助金额:
    $82.34万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Thiruma Arumugam
  • 依托单位:
The C-type lectin Mincle exemplifies a new mode of sterile inflammation in cardiovascular disease
  • 批准号:
    nhmrc : 1057846
  • 项目类别:
    Project Grants
  • 资助金额:
    $40.62万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Thiruma Arumugam
  • 依托单位:
Targeting aldosterone receptors in cerebrovascular disease
  • 批准号:
    nhmrc : 1064686
  • 项目类别:
    Project Grants
  • 资助金额:
    $57.19万
  • 财政年份:
    2014
  • 负责人:
    A/Pr Thiruma Arumugam
  • 依托单位:
海外基金