Workshop to Consider the Feasibility of a Sleep/Circadian Rhythms Gene Chip

考虑睡眠/昼夜节律基因芯片可行性的研讨会

• 批准号: 7277958
• 负责人: Mary A Carskadon
• 金额: $ 0.5万
• 依托单位: EMMA PENDLETON BRADLEY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277958
• 关键词: Academy; Address; Advanced Sleep Phase Syndrome; Affect; Alcohol dependence; American; Area; Behavior; Biological Models; Canis familiaris; Circadian Dysregulation; Circadian Rhythms; Classification; Communities; Disease; Drosophila genus; Educational workshop; Funding; Gene Chips; Gene Expression; Genes; Genetic; Goals; Growth; Human; Individual; Institutes; International; Knowledge; Laboratories; Medicine; Methods; Molecular; Molecular Biology; Narcolepsy; Neurobiology; Organism; Pattern; Physicians; Research; Research Personnel; Scientist; Sleep; Sleep Disorders; System; Techniques; Thinking; Time; United States National Institutes of Health; gene discovery; human data; member; relating to nervous system

DESCRIPTION (provided by applicant): Advances in sleep disorders medicine in the last 35 years have resulted in growth of the field from isolated individual physicians to a board-eligible subspecialty organized under the American Academy of Sleep Medicine with several thousand members. Sleep disorders are described and defined in an international classification system now in a second edition. The societal burden of sleep disorders-in addition to burdens arising from insufficient and ill-time sleep-is substantial. At least 10 separate institutes of the NIH currently fund research on diseases of the sleep and/or circadian rhythms systems. Basic sleep and circadian rhythms research have also progressed since the 1970s. The neurobiology of the circadian timing system has been dissected, and the molecular biology of circadian timing is unraveling as scientists use a variety of methods and organisms to identify key molecular components. Indeed, these advances has led to gene associations for circadian rhythms disorders, in particular the familial advanced sleep phase syndrome (FASPS). Recent progress has occurred in the molecular biology of sleep and sleep disorders. An important advance has come from the identification of sleep (or sleep-like behavior) in model systems, such as the fruit fly and in gene expression approaches. Scientists studying narcolepsy, a sleep disorder affecting humans and genetically transmitted in dogs, exposed an previously unknown neural system through genetic studies. The need for additional methods for gene association studies by investigators and clinicians in human sleep and circadian rhythms laboratories is now apparent. One approach used in other fields, e.g., alcohol and addiction studies, is to develop a targeted gene chip. Whether the sleep/circadian rhythms field is ready to take advantage of this method is uncertain. To examine this issue, a workshop will assess feasibility, identify parallel or alternative approaches, and make strides to prepare the community for such approaches. Investigators engaged in gene discovery in the sleep and circadian rhythms areas, clinicians whose knowledge of sleep disorders amenable to genetic approaches, human sleep researchers who have obtained phenotypic data from humans, and scientists engaged in gene chip research in other fields will come together to address these questions. This goal of this project is to hold a workshop for scientists and clinicians to examine a new method for performing genetic studies that may advance understanding of sleep disorders and sleep/wake patterns in humans. The technique that will be the focus of the workshop is a gene chip that would include genes thought to be important to regulating sleeping and waking. The workshop will also examine other methods and techniques that may help advance the genetic study of sleep and sleep disorders.

描述（由申请人提供）：在过去的35年中，睡眠障碍医学的进步导致该领域从孤立的个体医生发展成为美国睡眠医学学会组织的具有数千名成员的董事会资格的子专业。睡眠障碍在第二版的国际分类系统中进行了描述和定义。睡眠障碍的社会负担--除了睡眠不足和睡眠时间不当所造成的负担之外--是巨大的。目前，美国国立卫生研究院至少有10个独立的研究所为睡眠和/或昼夜节律系统疾病的研究提供资金。自20世纪70年代以来，基本的睡眠和昼夜节律研究也取得了进展。昼夜节律计时系统的神经生物学已经被解剖，而昼夜节律计时的分子生物学正在解开，因为科学家们使用各种方法和生物体来识别关键的分子成分。事实上，这些进展已经导致了昼夜节律紊乱的基因关联，特别是家族性提前睡眠阶段综合征（FASPS）。最近的进展发生在睡眠和睡眠障碍的分子生物学。一个重要的进展来自于在模型系统（如果蝇）和基因表达方法中识别睡眠（或类似睡眠的行为）。嗜睡症是一种影响人类并在狗身上遗传的睡眠障碍，科学家们通过遗传研究揭示了一种以前未知的神经系统。研究人员和临床医生在人类睡眠和昼夜节律实验室进行基因关联研究的额外方法的需求现在是显而易见的。在其他领域中使用的一种方法，例如，酒精和成瘾的研究，是开发一种有针对性的基因芯片。睡眠/昼夜节律领域是否准备好利用这种方法还不确定。为了研究这一问题，将举办一个讲习班，评估可行性，确定并行或替代办法，并努力使社区为采用这些办法做好准备。从事睡眠和昼夜节律领域基因发现的研究人员，睡眠障碍知识适用于遗传方法的临床医生，从人类获得表型数据的人类睡眠研究人员，以及从事其他领域基因芯片研究的科学家将共同解决这些问题。该项目的目标是为科学家和临床医生举办一个研讨会，研究一种进行遗传研究的新方法，以促进对人类睡眠障碍和睡眠/觉醒模式的理解。研讨会的重点技术是一种基因芯片，其中包括被认为对调节睡眠和清醒很重要的基因。研讨会还将研究其他可能有助于推进睡眠和睡眠障碍遗传研究的方法和技术。