Non-invasive cardio-pulmonary monitor for mice

小鼠无创心肺监护仪

• 批准号: 7286297
• 负责人: MARTIN Carl BARUCH
• 金额: $ 36.47万
• 依托单位: EMPIRICAL TECHNOLOGIES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7286297
• 关键词: Adult; Affect; Age; Agreement; Algorithms; Ambulatory Blood Pressure Monitoring; Anesthetics; Animal Experimentation; Animal Model; Animals; Antigens; Asthma; Biological Rhythm; Blood Pressure; Blood Pressure Monitors; Blood Vessels; CD4 Positive T Lymphocytes; Cardiac; Cardiopulmonary; Catheters; Cell physiology; Chest; Clinical; Computer software; Computers; Congestive Heart Failure; Consumption; Custom; Dendritic Cells; Development; Devices; Disclosure; Disease; Distributed Systems; Electrocardiogram; Electrodes; Engineering; Equipment; Exhibits; Frequencies; Functional disorder; GIRK4 subunit, G protein-coupled inwardly-rectifying potassium channel; GTP-Binding Proteins; General Anesthesia; Genetic; Genetic Engineering; Head; Health; Heart Atrium; Heart Block; Heart Rate; Hour; Inherited; Injection of therapeutic agent; Invasive; Investigation; Laboratories; Lead; Left; Letters; Longitudinal Studies; Lung; Manufacturer Name; Marketing; Measurement; Measures; Medical; Memory; Methods; Miniaturization; Modeling; Modification; Molecular; Monitor; Mouse Strains; Movement; Mus; Myocardial Infarction; Myotonic Dystrophy; Neuromuscular Diseases; Newborn Infant; None or Not Applicable; Numbers; Operative Surgical Procedures; Patients; Pattern; Peer Review; Performance; Phase; Physiologic Monitoring; Physiologic pulse; Physiological; Population; Potassium Channel; Predisposition; Publications; Pulse taking; Radio; Rate; Records; Research; Research Personnel; Respiration; Rivers; Sepsis; Services; Signal Transduction; Site; Skin; Standards of Weights and Measures; Stress Tests; System; T-Cell Receptor; T-Lymphocyte; Techniques; Technology; Testing; Tetracycline; Tetracyclines; Time; Transgenic Mice; Transgenic Organisms; Universities; Validation; Variant; Virginia; Week; Wild Type Mouse; Wireless Technology; atrioventricular node; base; computerized data processing; day; design; drug testing; gene therapy; genetic manipulation; graphical user interface; implantation; interest; methacholine; millisecond; miniaturize; mouse model; outcome forecast; physical state; receptor; research and development; respiratory; response; sensor; size; subcutaneous; systems research; transmission process

DESCRIPTION (provided by applicant): The results of the Phase I effort, during the course of which the physiological signals of eight mice were determined and correlated with established "golden standard" techniques, have demonstrated the feasibility of monitoring and identifying clearly distinguishable physiological signals by measuring the mouse's chest movements with a saddle-type sensor. More importantly, the results clearly established that this sensor can answer the need for the long-term and continuous monitoring of mobile mice, particularly those animals whose state of health is so precarious as a result of genetic intervention and age that invasive monitoring means are not an option. As part of the Phase II effort the system will be miniaturized so that the entire sensing assembly can be moved onto the mouse and a miniature wireless transmission system will be integrated into the sensor system. The real-time signal processing algorithms will be optimized and a computer-based graphical user interface (GUI) completed. In order to validate the performance of the sensing system, two studies will be performed at the University of Virginia on mouse populations whose fragile state of health does not permit invasive monitoring. One study will involve mice with inducible myotonic dystrophy, while the other will study asthmatic mice. An alliance has been formed with a well-known manufacturer of physiological monitoring equipment to commercialize the product. The need for the long-term monitoring of cardiopulmonary rhythms in mice is growing along with an increasing population of mice strains that are being used to test drug responses, genetic engineering attempts, and other factors that can affect these biological rhythms. This sensor technology can answer the need for the long-term and continuous monitoring of mobile mice, particularly those animals whose state of health is precarious as a result of genetic intervention and age that invasive monitoring means are not an option.

描述（由申请人提供）：第一阶段工作的结果，在此过程中，确定了8只小鼠的生理信号并与已建立的“金标准”技术相关联，已经证明了通过用鞍型传感器测量小鼠的胸部运动来监测和识别可清楚区分的生理信号的可行性。更重要的是，结果清楚地表明，这种传感器可以满足对移动的小鼠进行长期和连续监测的需要，特别是那些由于遗传干预和年龄而健康状况不稳定的动物，侵入性监测手段不是一种选择。 作为第二阶段工作的一部分，该系统将小型化，以便整个传感组件可以移动到鼠标上，微型无线传输系统将集成到传感器系统中。将优化实时信号处理算法，并完成基于计算机的图形用户界面（GUI）。为了验证传感系统的性能，弗吉尼亚大学将对健康状况脆弱不允许侵入性监测的小鼠种群进行两项研究。一项研究将涉及患有可诱导强直性肌营养不良症的小鼠，而另一项研究将研究哮喘小鼠。 已与一家著名的生理监测设备制造商结成联盟，将该产品商业化。 随着用于测试药物反应、基因工程尝试和其他可能影响这些生物节律的因素的小鼠品系数量的增加，对小鼠心肺节律的长期监测的需求沿着增长。这种传感器技术可以满足长期和连续监测移动的小鼠的需要，特别是那些由于遗传干预和年龄而健康状况不稳定的动物，侵入性监测手段不是一种选择。