Non-invasive cardiopulmonary monitor for mice

小鼠无创心肺监护仪

• 批准号: 6741565
• 负责人: MARTIN Carl BARUCH
• 金额: $ 9.95万
• 依托单位: EMPIRICAL TECHNOLOGIES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2004-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741565
• 关键词: biomedical equipment development; biosensor device; blood pressure; cardiovascular function; computer system design /evaluation; electrocardiography; fiber optics; heart rate; laboratory mouse; monitoring device; noninvasive diagnosis; pulmonary respiration

DESCRIPTION (provided by applicant): The study of long-term variation in physiological cardiopulmonary rhythms in mice is rapidly expanding. The reason is that there are an ever-increasing number of strains of mice that have been genetically engineered to test scientific hypotheses about the molecular mechanisms of the cellular processes that control these biological rhythms. Since mice are so small, conventional recording systems need significant modification (indwelling vascular catheters) or are not applicable at all (skin electrodes). The development of a non-invasive sensor system for the continuous and reliable monitoring of respiratory rate, HR, and possibly blood pressure trends in mice is proposed. The sensor is based on a fiber-optic coupler sensor technology that has proven its applicability to physiological monitoring in humans in a number of applications. The sensor technology, which showed promising results in preliminary experiments, is very sensitive and scalable in size. The design of the sensor system, once it has been optimized using a "synthetic" mouse, will be tested on 8-10 mice that have been fitted with an EKG monitoring system commonly used in the mouse research community. The data will be analyzed and the reliability of the approach assessed using different algorithms, including wavelet transforms.

描述（由申请人提供）：对小鼠生理心肺节律的长期变化的研究正在迅速扩大。原因是，越来越多的小鼠品系经过基因工程改造，用于测试有关控制这些生物节律的细胞过程的分子机制的科学假设。由于小鼠非常小，传统的记录系统需要进行重大修改（留置血管导管）或根本不适用（皮肤电极）。 建议开发一种非侵入性传感器系统，用于连续可靠地监测小鼠的呼吸频率、心率和可能的血压趋势。该传感器基于光纤耦合器传感器技术，该技术已在多种应用中证明其适用于人体生理监测。该传感器技术在初步实验中显示出有希望的结果，非常灵敏且尺寸可扩展。 传感器系统的设计一旦使用“合成”小鼠进行了优化，将在 8-10 只配备了小鼠研究界常用的 EKG 监测系统的小鼠上进行测试。 将使用不同的算法（包括小波变换）对数据进行分析并评估该方法的可靠性。