Neonatal respiratory distress related to colonization wi

与定植相关的新生儿呼吸窘迫

• 批准号: 7334194
• 负责人: rachel schneerson
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7334194
• 关键词: Neonatal; respiratory; distress; related; colonization

About 25% of women of childbearing age carry GBS in their rectum or vagina. Half of their newborns acquire GBS at birth; 98% are said to be asymptomatic. Phospholipids from group B streptococcal (GBS) cell wall cause pulmonary hypertension in experimental animals. When exposed to penicillin, Streptococcus mutans release phospholipids immediately. We hypothesize that newborns colonized with GBS receive bacterial phospholipids leading to pulmonary hypertension and respiratory distress, especially in newborns of penicillin-treated mothers. Analysis of data from 1,610 colonized newborns of >32 weeks gestation without early-onset disease showed that 8.8% had signs of respiratory distress within 48 hours after birth. This effect was enhanced by penicillin use during labor. Our findings support the association of neonatal respiratory distress with asymptomatic GBS colonization and with penicillin use during labor. A prospective study to relate the levels of serum bacterial phospholipids to the occurrence of respiratory distress in newborns of mothers colonized by GBS, and the effects of penicillin use during labor on the occurrence of respiratory distress is underway. Assay to measure bacterial phospholipids in biological specimens in mothers and newborns are being developed in collaboration with Dr. alfred Yergey at NICHD.

大约25%的育龄妇女在她们的直肠或阴道中携带GBS。他们的新生儿中有一半在出生时就感染了GBS；98%的人据说没有症状。B群链球菌(GBS)细胞壁的磷脂可引起实验动物的肺动脉高压。当接触青霉素时，变形链球菌会立即释放磷脂。我们假设，患有GBS的新生儿接受细菌磷脂，导致肺动脉高压和呼吸窘迫，特别是在接受青霉素治疗的母亲的新生儿中。对1,610名妊娠32周且无早发性疾病的定居新生儿的数据分析显示，8.8%的新生儿在出生后48小时内出现呼吸窘迫迹象。在分娩过程中使用青霉素可以增强这种效果。我们的发现支持新生儿呼吸窘迫与无症状的GBS定植和在分娩期间使用青霉素有关。一项前瞻性研究正在进行中，旨在探讨血清细菌磷脂水平与新生儿呼吸窘迫发生的关系，以及分娩期间使用青霉素对呼吸窘迫发生的影响。与NICHD的Alfred Yergey博士合作，正在开发一种检测母亲和新生儿生物标本中细菌磷脂的方法。