PEDIATRIC MALIGNANCIES PROGRAM

儿科恶性肿瘤计划的目标是通过基础和临床翻译来改善 研究，癌症儿童的结果。儿童癌症在形态上是独一无二的，其组织 起源和行为。它们提供了一个机会来了解正常发育和 恶性肿瘤的变异，遗传与环境的相互作用，以及癌症的后遗症 治疗。该计划的目的如下：(1)阐明霍奇金淋巴瘤的分子发病机制 通过识别重要的基因、蛋白质和途径来识别儿童癌症；(2)将这些信息转化为 改进诊断、分类、结果预测、治疗选择和流行病学 研究；(3)开发和进行临床I、II和III期试验以提高存活率；(4)研究晚期 治疗的效果和改善幸存者的生活质量；和(5)培训研究员、住院医生和学生 在儿科恶性肿瘤和导师初级教员的基础和临床研究培训奖。这个 儿科恶性疾病计划有来自10个不同部门的25名成员。主要研究内容 儿科恶性肿瘤计划的兴趣是儿科恶性肿瘤的分子和基因组研究 (特别是神经母细胞瘤、CMS瘤、白血病和视网膜母细胞瘤)， 神经母细胞瘤、脑瘤和白血病，以及儿童癌症的后遗症和流行病学。这个 该计划的目标通过与癌症中心项目(如造血)的密切协同而得到加强 恶性肿瘤、神经肿瘤学和烟草控制，以及与科学家在 其他基础科学项目，如癌症和免疫、细胞周期和信号传递以及癌症 遗传学，和核心。该计划在上一次预算中总共有4,444,595美元的同行评审支持 年。该方案有17%的方案内出版物和40%的方案间出版物。 演出现场(S)(组织、市、州) 加州大学旧金山分校综合癌症中心 加利福尼亚州旧金山 PHS 398/2590(09/04版)，儿科恶性肿瘤计划

The goal of the Pediatric Malignancies Program is to improve, through basic and clinical translational research, the outcome for children with cancer. Pediatric cancers are unique in their morphology, tissues of origin and behavior. They provide an opportunity to understand the link between normal development and the aberrations of malignancy, the interactions of genetics and environment, and the late effects of treatment. The aims of the program are the following: (1) to elucidate the molecular pathogenesis of childhood cancer by identifying important genes, proteins and pathways; (2) to translate this information into improved diagnosis, classification, prediction of outcome, and treatment selection and epidemiological studies; (3) to develop and conduct clinical Phase I, II and III trials to improve survival; (4) to study the late effects of therapy and improve the quality of life for survivors; and (5) to train fellows, residents and students in pediatric malignancies and mentor junior faculty with basic and clinical research training awards. The Pediatric Malignancies Program has 25 members from 10 different departments. The main research interests of the Pediatric Malignancies Program are molecular and genomic studies of pediatric malignancies (particularly neuroblastoma, CMS tumors, leukemias and retinoblastoma), developmental therapeutics in neuroblastoma, brain tumors, and leukemia, and late effects and epidemiology of childhood cancer. The goals of the Program are enhanced by close synergy with Cancer Center Programs such as Hematopoietic Malignancies, Neurologic Oncology, and Tobacco Control, as well as many interactions with scientists in other, basic science Programs, such as Cancer and Immunity, Cell Cycling and Signaling, and Cancer Genetics, and with the Cores. The Program has $4,444,595 Total peer reviewed support for the last budget year. The Program has 17% intra-programmatic and 40% inter-programmatic publications. PERFORMANCE SITE(S) (organization, city, state) UCSF Comprehensive Cancer Center San Francisco, California PHS 398/2590 (Rev. 09/04) Page Pediatric Malignancies Program