PEDIATRIC MALIGNANCIES PROGRAM

儿科恶性肿瘤计划

• 批准号: 7506418
• 负责人: KATHERINE Kurshan MATTHAY
• 金额: $ 6.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-25 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7506418
• 关键词: Award; Basic Science; Behavior; Brain Neoplasms; Budgets; California; Cancer Center; Cell Cycle; Child; Childhood; Cities; Classification; Clinical; Clinical Research; Comprehensive Cancer Center; Development; Developmental Therapeutics Program; Diagnosis; Environment; Epidemiologic Studies; Epidemiology; Faculty; Gene Proteins; Genetic; Genomics; Goals; Hematopoietic Neoplasms; Immunity; Late Effects; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Mentors; Molecular; Morphology; Neuroblastoma; Neurologic Oncology; Outcome; Outcomes Research; Pathogenesis; Pathway interactions; Peer Review; Phase; Publications; Quality of life; Research; Research Training; Retinoblastoma; San Francisco; Scientist; Selection for Treatments; Signal Transduction; Students; Survivors; Tissues; Training; Translating; Translational Research; cancer genetics; improved; interest; leukemia; member; performance site; programs; tobacco control; tumor

The goal of the Pediatric Malignancies Program is to improve, through basic and clinical translational research, the outcome for children with cancer. Pediatric cancers are unique in their morphology, tissues of origin and behavior. They provide an opportunity to understand the link between normal development and the aberrations of malignancy, the interactions of genetics and environment, and the late effects of treatment. The aims of the program are the following: (1) to elucidate the molecular pathogenesis of childhood cancer by identifying important genes, proteins and pathways; (2) to translate this information into improved diagnosis, classification, prediction of outcome, and treatment selection and epidemiological studies; (3) to develop and conduct clinical Phase I, II and III trials to improve survival; (4) to study the late effects of therapy and improve the quality of life for survivors; and (5) to train fellows, residents and students in pediatric malignancies and mentor junior faculty with basic and clinical research training awards. The Pediatric Malignancies Program has 25 members from 10 different departments. The main research interests of the Pediatric Malignancies Program are molecular and genomic studies of pediatric malignancies (particularly neuroblastoma, CMS tumors, leukemias and retinoblastoma), developmental therapeutics in neuroblastoma, brain tumors, and leukemia, and late effects and epidemiology of childhood cancer. The goals of the Program are enhanced by close synergy with Cancer Center Programs such as Hematopoietic Malignancies, Neurologic Oncology, and Tobacco Control, as well as many interactions with scientists in other, basic science Programs, such as Cancer and Immunity, Cell Cycling and Signaling, and Cancer Genetics, and with the Cores. The Program has $4,444,595 Total peer reviewed support for the last budget year. The Program has 17% intra-programmatic and 40% inter-programmatic publications. PERFORMANCE SITE(S) (organization, city, state) UCSF Comprehensive Cancer Center San Francisco, California PHS 398/2590 (Rev. 09/04) Page Pediatric Malignancies Program

儿科恶性肿瘤项目的目标是通过基础和临床转化来改善 研究，癌症儿童的结果。儿童癌症在形态、组织方面具有独特性 起源和行为。它们提供了一个了解正常发展和 恶性肿瘤的畸变、遗传和环境的相互作用以及晚期影响 治疗。该计划的目标如下：（1）阐明疾病的分子发病机制。 通过识别重要的基因、蛋白质和途径来治疗儿童癌症； (2) 将这些信息翻译成 改进诊断、分类、结果预测以及治疗选择和流行病学 研究； (3) 开发和开展临床I、II和III期试验以提高生存率； (4)学习后期 治疗效果并改善幸存者的生活质量； (5) 培训研究员、住院医生和学生 从事儿科恶性肿瘤研究，并为初级教师提供基础和临床研究培训奖项的指导。这 儿科恶性肿瘤项目有来自 10 个不同科室的 25 名成员。主要研究 儿科恶性肿瘤项目的兴趣是儿科恶性肿瘤的分子和基因组研究 （特别是神经母细胞瘤、CMS 肿瘤、白血病和视网膜母细胞瘤）、发育疗法 神经母细胞瘤、脑肿瘤和白血病，以及儿童癌症的晚期影响和流行病学。这 该计划的目标通过与造血等癌症中心计划的密切协同作用得到加强 恶性肿瘤、神经肿瘤学和烟草控制，以及与科学家的许多互动 其他基础科学项目，例如癌症和免疫、细胞周期和信号转导以及癌症 遗传学，以及核心。该计划对上一预算的同行评审支持总额为 4,444,595 美元 年。该计划有 17% 的计划内出版物和 40% 的计划间出版物。 绩效站点（组织、城市、州） 加州大学旧金山分校综合癌症中心 加利福尼亚州旧金山 PHS 398/2590（修订版 09/04）页码 儿科恶性肿瘤计划