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VIRAL VECTOR CORE

病毒载体核心

基本信息

批准号：
7284637
负责人：
JULIE JOHNSTON
金额：
$ 6.45万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7284637
关键词：
Adenovirus Vector Adenoviruses Archives Area Arts Basic Science Biological Assay Biology Clinical Trials Communities Data Databases Dependovirus Development Diabetes Mellitus Documentation Endocrine System Diseases Engineering Facility Construction Funding Category Family Gene Transfer Generations Genetic Guidelines Head Human Resources Industry Institutes Laboratories Leadership Lentivirus Vector Location Maps Mentorship Molecular Biology Monitor Non-Viral Vector Occupations Online Systems Pan Genus Pan troglodytes Paper Performance Postdoctoral Fellow Production Quality Control Range Reagent Recruitment Activity Regulation Research Research Personnel Resources Running Services Standardization Subfamily lentivirinae Technology Time Vaccines Validation Viral Vector Virus Work adeno-associated viral vector base chiron vaccine design experience gene therapy gene transfer vector improved in vivo innovation interest member novel preclinical study programs recombinant virus repository skills success technology development vector viral DNA virology

项目摘要

VIRAL VECTOR CORE: Director-J. Johnston The main objective of the Vector Core is to provide DERC center members access to state-of-theart vector technology for preclinical studies. In order to facilitate vector creation and production, the professional staff, using a state-of-the-art facility, will carry out the following: 1) Production of viral vectors derived from adeno-associated viruses (AAV), adenoviruses, and lentiviruses as well as the production of non-viral vectors for use in basic research; 2) Work with DERC Investigators to develop vectors or recombinant viruses specifically of use to DERC members; 3) Development of gene transfer vectors that will be superior to those of previous generations; 4) Submission of the vectors produced to the Bioassay Core to determine the quantity, purity and potency of the vectors produced; 5) Development of a web-based database to enable DERC members to request services, monitor the status of vector production, and access historical data on vectors produced by their laboratory.

病毒载体核心：Director-J。约翰斯顿向量核心的主要目标是为DERC中心成员提供访问最先进技术的途径临床前研究的载体技术。为了促进媒介的创建和生产，专业工作人员将使用最先进的设施进行以下工作：1)生产病毒来自腺相关病毒(AAV)、腺病毒和慢病毒的载体以及生产用于基础研究的非病毒载体；2)与DERC调查人员合作开发专门用于DERC成员的载体或重组病毒；3)开发将优于前几代的基因转移载体；4)提交将载体生产到生物测定核心以确定载体的数量、纯度和效力制作；5)开发一个基于网络的数据库，使经社文中心成员能够请求服务，监控病媒生产的状态，并访问由他们的实验室。