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Viral Vector Core

病毒载体核心

基本信息

批准号：
9918904
负责人：
JULIE JOHNSTON
金额：
$ 2.8万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9918904
关键词：
Adenovirus Vector Adipose tissue Animal Model Basic Science Biological Assay Biological Models Canis familiaris Clinical Clinical Trials Cloning Committee Members Communities Consultations Control Groups Country DNA amplification Development Diabetes Mellitus Endocrine Experimental Designs Family suidae Felis catus Future Gene Delivery Gene Transduction Agent Generations Guidelines Heart Human International Laboratories Laboratory Research Lentivirus Vector Liver Mediating Methodology Methods Molecular Muscle National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases Pennsylvania Pharmacology and Toxicology Phase Process Production Quality Control Regulation Research Research Personnel Resources Serotyping Services Sheep Technology Therapeutic Studies Time Translational Research Universities Validation Viral Viral Vector Work adeno-associated viral vector base clinical application clinical candidate community center design experience gene therapy interest member nonhuman primate novel pre-clinical preclinical study programs ranpirnase research study vector virtual

项目摘要

The Viral Vector Core is a critical resource for Diabetes Research Center (DRC) members interested in the use of viral vectors for gene therapy and basic research applications. The Vector core provides adenoviral vectors, adeno-associated viral vectors (AAV) and lentiviral vectors and offers a full range of services including cloning, DNA amplification and characterization, vector design, and consultation. The Core is located within one of the premier gene therapy research laboratories in the country and specializes in the production and distribution of novel AAV serotype vectors. The objectives of the DRC Vector Core are as follows: Using state-of-the-art facilities and dedicated professional staff, the Core will: (1) provide DRC Center members with access to high quality vector technologies for basic research and preclinical studies; (2) work with DRC executive committee members to develop vectors specifically for use by DRC members; (3) transition newly created vectors with superior transduction profiles developed in Penn laboratories to the Core for validation and distribution to DRC members and (4) provide consultation to DRC members for vector construction and experimental design. The overall objective of the DRC Vector Core is to serve investigators at Penn and the surrounding scientific community (e.g. Jefferson and Temple Universities) and aid in the advancement of diabetes-related research.

病毒载体核心是糖尿病研究中心（DRC）成员感兴趣使用的关键资源