METHYLATION IN ESTABLISHMENT & MAINTENANCE OF LATENCY IN GAMMAHERPES VIRUSES

甲基化的建立

• 批准号: 7349226
• 负责人: JANICE MARIE MOSER
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349226
• 关键词: methylation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human herpesviruses, such as Epstein Barr virus and Kaposi?s sarcoma-associated herpesvirus, have been associated with the development of lymphomas, as well as other tumors. Since ?-herpesviruses have an extremely limited host range, study of these viruses in vivo has been difficult. Murine gamma-herspesvirus 68 (?HV68) is providing valuable insights into the understanding of the factors involved with the establishment and maintenance of latency by ?-herpesviruses. One of the main factors critical in the establishment of latency is the ability of the virus to silence the promoters of genes necessary for the lytic cycle of the virus. The key mechanism in silencing both cellular and viral promoters is increased methylation of CpG motifs by cellular methyltransferases.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。人类疱疹病毒，如爱泼斯坦巴尔病毒和卡波西？肉瘤相关疱疹病毒与淋巴瘤以及其他肿瘤的发生有关。从什么时候开始？-疱疹病毒具有极其有限的宿主范围，在体内研究这些病毒是困难的。鼠γ疱疹病毒68（？HV 68）为理解与潜伏期的建立和维持有关的因素提供了有价值的见解。疱疹病毒潜伏期建立的关键因素之一是病毒沉默病毒裂解周期所需基因启动子的能力。沉默细胞和病毒启动子的关键机制是细胞甲基转移酶增加CpG基序的甲基化。