ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们发现，N。在学习安全线索的过程中，大脑脑源性神经营养因子转录物被恐惧学习不同地激活，杏仁核的基底外侧而不是内侧核的NMDA拮抗剂阻断嗅觉介导的恐惧增强惊吓，杏仁核中CREB的过表达促进了行为学相关学习模型中的恐惧学习，性腺类固醇调节我们的焦虑模型，但不调节条件性恐惧。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have found that the n. accumbens does not seemed to be involved in learning about safety cues, the brain brain-derived neurotrophic factor transcripts are differentially activated by fear learning, that NMDA antagonists into the basolateral, but not the medial nucleus of the amygdala block olfactory-mediated fear-potentiated startle, that overexpression of CREB in the amygdala facilitates fear learning in an ethologically relevant model of learning, and that gonadal steroids modulate our models of anxiety, but not conditioned fea