EARLY LIFE STRESS IN NON-HUMAN PRIMATES AND HUMANS

非人类灵长类动物和人类的早期生活压力

• 批准号: 8357567
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357567
• 关键词: Funding; Grant; Human; Learning; Life Stress; Macaca mulatta; Measures; Monkeys; National Center for Research Resources; Patients; Post-Traumatic Stress Disorders; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Safety; Signal Transduction; Source; Symptoms; Testing; United States National Institutes of Health; Work; cost; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period, in other work we found that patients with PTSD do not show normal conditioned inhibition which means we have an objective measure of one of the core symptoms of PTSD, namely the inability to feel safe. We have set up the AX+, BX- in rhesus monkeys at Yerkes and have found good safety signal learning in 3 control and 1 maternally separated monkeys. In the other two separated monkeys they failed show inhibitory learning. This work will now continue in 34 more monkeys funded by a Challenge grant for which I hired a new non-human primate technician, to do this work. She has now completed testing on 12 more monkeys and is almost done with another 6 monkeys.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 报告期内，我们在其他工作中发现PTSD患者没有表现出正常的条件性抑制，这意味着我们对PTSD的核心症状之一，即缺乏安全感有了客观的衡量标准。 我们在 Yerkes 的恒河猴中设置了 AX+、BX-，并在 3 只对照猴和 1 只母系分离的猴子中发现了良好的安全信号学习能力。 在另外两只分开的猴子中，它们未能表现出抑制性学习。 这项工作现在将在另外 34 只猴子身上继续进行，这些猴子是由挑战赛资助的，为此我聘请了一位新的非人类灵长类技术人员来完成这项工作。 她现在已经完成了另外 12 只猴子的测试，另外 6 只猴子的测试也即将完成。