EARLY LIFE STRESS IN NON HUMAN PRIMATES AND HUMANS

非人类灵长类动物和人类的早期生活压力

• 批准号: 8357416
• 负责人: MICHAEL NMN DAVIS
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357416
• 关键词: Amygdaloid structure; Corticotropin; Feedback; Fright; Funding; Grant; Human; Hyperactive behavior; Life Stress; National Center for Research Resources; Post-Traumatic Stress Disorders; Primates; Principal Investigator; Reporting; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period, subjects with PTSD failed to inhibit fear and this was correlated with baseline and post-dexamethsone ACTH in PTSD subjects. These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD. FUNDING SOURCE: This grant has now terminated.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 在报告期间，PTSD受试者未能抑制恐惧，这与PTSD受试者的基线和地塞米松后ACTH相关。这些结果表明，受损的恐惧抑制和相关的HPA反馈的变化可能反映了PTSD受试者的杏仁核过度活跃。 资金来源： 该补助金现已终止。