BIOLOGICAL IMPRINT OF CHILDHOOD NEGLECT

童年被忽视的生物学印记

• 批准号: 7349474
• 负责人: SETH D POLLAK
• 金额: $ 2.72万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349474
• 关键词: BIOLOGICAL; IMPRINT; CHILDHOOD; NEGLECT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether hormones critical in the establishment of social bonds and regulation of emotional behaviors in children are affected by their early social experiences. The formation of social attachments is a critical component of human relationships. Infants begin to bond to their caregivers from the moment of birth, and these social bonds continue to provide regulatory emotional functions throughout adulthood. It is difficult to examine the interactions between social experience and the biological origins of these complex behaviors because children undergo both brain development and accumulate social experience at the same time. We had a rare opportunity to examine children who were reared in extremely aberrant social environments where they were deprived of the kind of care-giving typical for our species. The present experiment in nature provides insight into the role of early experience on the brain systems underlying the development of emotional behavior. These data indicate that the vasopressin and oxytocin neuropeptide systems, which are critical in the establishment of social bonds and the regulation of emotional behaviors, are affected by early social experience. The results of this experiment suggest a potential mechanism whose atypical function may explain the pervasive social and emotional difficulties observed in many children who have experienced aberrant care-giving. The present findings are consistent with the view that there is a critical role for early experience in the development of the brain systems underlying basic aspects of human social behavior. This research used techniques developed by WNPRC Assay Services.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。探讨儿童早期社会经历对社会关系建立和情绪行为调节的关键激素是否有影响。社会依附的形成是人际关系的重要组成部分。婴儿从出生的那一刻起就开始与他们的照顾者建立联系，这些社会联系在整个成年期继续提供调节情绪的功能。要检验社会经验和这些复杂行为的生物学起源之间的相互作用是困难的，因为儿童在经历大脑发育的同时也在积累社会经验。我们有一个难得的机会来研究那些在极端异常的社会环境中长大的孩子，他们被剥夺了我们物种典型的照顾。目前在自然界进行的实验提供了对早期经历在情绪行为发展基础上的大脑系统中的作用的深入了解。这些数据表明，抗利尿激素和催产素神经肽系统在社会关系的建立和情绪行为的调节中起着至关重要的作用，它们受到早期社会经验的影响。这个实验的结果提出了一个潜在的机制，它的非典型功能可以解释在许多经历过异常照顾的儿童中观察到的普遍的社会和情感困难。目前的研究结果与早期经验在人类社会行为基本方面的大脑系统发展中起关键作用的观点是一致的。这项研究使用了WNPRC化验服务公司开发的技术。