BIOLOGICAL IMPRINT OF CHILDHOOD NEGLECT

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。确定在建立社会联系和调节儿童情绪行为中起关键作用的激素是否受到他们早期社会经验的影响。 社会依恋的形成是人际关系的重要组成部分。婴儿从出生的那一刻起就开始与他们的照顾者建立联系，这些社会联系在整个成年期继续提供调节情绪的功能。很难研究社会经验和这些复杂行为的生物学起源之间的相互作用，因为儿童同时经历大脑发育和积累社会经验。我们有一个难得的机会来研究那些在极端异常的社会环境中长大的孩子，他们被剥夺了我们物种典型的照顾。目前在自然界中的实验提供了对早期经验在大脑系统中的作用的深入了解，这些大脑系统是情绪行为发展的基础。这些数据表明，加压素和催产素神经肽系统，这是建立社会债券和情绪行为的调节，是至关重要的，受到早期社会经验。本实验的结果表明，一个潜在的机制，其非典型功能可以解释普遍的社会和情感的困难，观察到许多儿童谁经历了异常的照顾。目前的研究结果与这样一种观点相一致，即早期经验在人类社会行为基本方面的大脑系统发展中起着关键作用。这项研究使用了WNPRC Assay Services开发的技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To determine whether hormones critical in the establishment of social bonds and regulation of emotional behaviors in children are affected by their early social experiences. The formation of social attachments is a critical component of human relationships. Infants begin to bond to their caregivers from the moment of birth, and these social bonds continue to provide regulatory emotional functions throughout adulthood. It is difficult to examine the interactions between social experience and the biological origins of these complex behaviors because children undergo both brain development and accumulate social experience at the same time. We had a rare opportunity to examine children who were reared in extremely aberrant social environments where they were deprived of the kind of care-giving typical for our species. The present experiment in nature provides insight into the role of early experience on the brain systems underlying the development of emotional behavior. These data indicate that the vasopressin and oxytocin neuropeptide systems, which are critical in the establishment of social bonds and the regulation of emotional behaviors, are affected by early social experience. The results of this experiment suggest a potential mechanism whose atypical function may explain the pervasive social and emotional difficulties observed in many children who have experienced aberrant care-giving. The present findings are consistent with the view that there is a critical role for early experience in the development of the brain systems underlying basic aspects of human social behavior. This research used techniques developed by WNPRC Assay Services.