DIAGNOSTIC AND CLINICAL PATHOLOGY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。比较病理学分部为中心各分部、附属科学家、合作科学家和其他利用该中心资源的美国科学研究人员提供解剖和临床病理学服务。诊断实验室在识别圈养的非人类灵长类动物的某些自然疾病方面发挥着关键作用，这些疾病可能会发展成人类各种疾病的动物模型。该中心开发的针对人类疾病的非人类灵长类动物模型包括猿猴艾滋病、结肠炎和结肠癌以及肾小球肾炎。利用SIV/恒河猴模型进行的艾滋病发病机制研究仍然是比较病理学司开展的研究的主要重点。最近描述的非人类灵长类动物的情况目前正在研究的模型开发包括SV40诱导的肿瘤发生，SIV感染的恒河猴的动脉病变，恒河猴的隐孢子虫感染，以及SIV感染的恒河猴的禽分枝杆菌感染的发病机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Comparative Pathology provides anatomic and clinical pathology services to the various Divisions of the Center, affiliated scientists, collaborative scientists, and other scientific investigators from the USA who utilize the resources of this center. The diagnostic laboratory plays a critical role in the recognition of certain natural diseases of captive nonhuman primates that may be developed into animal models for various diseases of humans. Examples of nonhuman primate models for human diseases that have been developed at the Center include simian AIDS, colitis and colonic carcinoma, and glomerulonephritis. AIDS pathogenesis studies, using the SIV/rhesus macaque model, remain a major focus of the research conducted in the Division of Comparative Pathology. More recently described conditions of nonhuman primates that are currently being investigated for model development include SV40-induced oncogenesis, arteriopathy in SIV-infected rhesus, cryptosporidial infection in rhesus, and the pathogenesis of Mycobacterium avium infection in SIV-infected rhesus.