NIAMS Multidisciplinary Clinical Research Center

描述（由申请人提供）：拟议的UCSF多学科临床研究中心计划（UCSF MCRC）的广泛目标是通过发现影响这些结果的医学，人口统计学和背景因素来改善患有各种形式风湿性疾病的人的结果。这一总体目标是通过风湿性疾病临床研究的综合计划来实现的，包括但不限于MCRC内的临床研究;通过在整个UCSF中作为此类临床研究的催化剂;以及通过对风湿性疾病临床研究人员的系统培训。 MCRC包括一个行政单位，方法核心，三个五年期项目和一个三年期发展和可行性研究（D&F）。MCRC的参与者跨越三个UCSF学校（医学，护理和牙科）和加州大学戴维斯分校，包括九个独立学术单位的代表，包括UCSF GCRC。该中心的主任和副主任分别是爱德华·叶林博士和林赛·克里斯韦尔博士。核心股主任是帕特里夏·卡茨博士。该委员会的日常活动由一个执行委员会指导。该中心的战略监督由内部（UCSF）和外部咨询委员会提供。 MCRC的研究基于对患有两种特定疾病（系统性红斑狼疮（SLE）和风湿性关节炎（RA））的人的原始数据的分析，以及对患有更广泛肌肉骨骼疾病的人的二级数据的分析。具体的五年项目是：“SLE健康差异中社会人口和遗传因素的相互作用”;“SLE和就业：个人和背景因素的影响”;以及“中年肌肉骨骼疾病是否导致老年人残疾？". D&F研究是：SLE患者APLA的神经精神症状和MRI标记物。

DESCRIPTION (provided by applicant): The broad aim of the proposed UCSF Multidisciplinary Clinical Research Center Program (UCSF MCRC) is to improve outcomes for persons with various forms of rheumatic diseases by discovery of the medical, demographic, and contextual factors affecting those outcomes. This overarching aim is pursued by a comprehensive program of clinical research in the rheumatic diseases, including but not limited to that within the MCRC; by serving as a catalyst for such clinical research throughout UCSF; and by systematic training of clinical investigators in the rheumatic diseases. The MCRC consists of an Administrative Unit, Methodology Core, three five-year projects, and a three-year Development and Feasibility (D&F) Study. The participants in the MCRC span three UCSF schools (Medicine, Nursing, and Dentistry) and UC Davis and include representatives of nine discrete academic units, including the UCSF GCRC. The Center's Director and Associate Director are Drs. Edward Yelin and Lindsey Criswell, respectively. The Director of the Core Unit is Dr. Patricia Katz. The activities of the MCRC are guided on a day-to-day basis by an Executive Committee. Strategic oversight of the Center is provided by Internal (UCSF) and External Advisory Committees. The research in the MCRC is based on analysis of primary data on persons with two specific diseases, Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA), and on analysis of secondary data on persons with a broader array of musculoskeletal conditions. The specific five-year projects are: "The Interplay of Sociodemographic and Genetic Factors in SLE Health Disparities"; "SLE and Employment: The Impact of Individual and Contextual Factors"; and, "Do Mid-Life Musculoskeletal Conditions Lead to Disability in the Elderly?". The D&F study is: Neuropsychiatric Symptoms and MRI Markers in SLE Patients APLA".