Improving Learning in MS: A Randomized Clinical Trial

改善多发性硬化症的学习：随机临床试验

• 批准号: 7408119
• 负责人: NANCY D. CHIARAVALLOTI
• 金额: $ 64.96万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7408119
• 关键词: Address; Appendix; Area; Behavioral; Clinical; Cognitive; Cognitive deficits; Cognitive remediation; Control Groups; Daily; Data; Documentation; Double-Blind Method; Education; Effectiveness; Effectiveness of Interventions; Evaluation; Funding; Imagery; Impairment; Individual; Intervention; Learning; Length; Life; Literature; Long-Term Effects; Maintenance; Measurement; Measures; Medical; Memory; Memory impairment; Multiple Sclerosis; Neurologic; Occupational; Outcome; Outcome Assessment; Participant; Patient Self-Report; Patients; Performance; Personal Satisfaction; Persons; Pilot Projects; Placebo Control; Placebos; Planet Mars; Population; Process; Protocols documentation; Quality of life; Questionnaires; Randomized; Randomized Clinical Trials; Rate; Recommendation; Rehabilitation Research; Rehabilitation therapy; Research; Research Personnel; Research Priority; Sample Size; Sampling; Self Efficacy; Social Functioning; Societies; Standards of Weights and Measures; Techniques; Testing; Time; Training; Traumatic Brain Injury; Treatment Efficacy; Treatment Protocols; cognitive function; design; disability; follow-up; improved; instrument; mild neurocognitive impairment; neuropsychological; programs; remediation; symptom management; treatment effect

DESCRIPTION (provided by applicant): The Advisory Board of the NCMRR has underscored the need for "studies of the effectiveness of medical rehabilitation interventions.., using new and precise quantitative measurements of impairment, including functional and societal limitations and disability." The current proposal addresses this recommendation through a double-blind, placebo-control randomized clinical trial examining the efficacy of memory retraining in Multiple Sclerosis (MS). Impairment in higher level cognitive processing, such as new learning and memory, is one of the most common deficits in individuals with MS and such deficits have been shown to exert significant negative impact on multiple aspects of everyday life, including occupational and social functioning. Despite these findings, few studies have attempted to treat these cognitive deficits in order to improve the everyday functioning of individuals with MS. Through a small randomized clinical trial, we found that individuals with MS with documented memory impairment show a significant improvement in their memory performance following a treatment protocol utilizing imagery and context to facilitate learning. The current proposal will replicate this finding and further evaluate (a) the impact of the treatment on everyday functioning, (b) the long term efficacy of the treatment and (c) the utility of booster sessions in facilitating long-term treatment effects. We will randomly assign individuals with MS, with documented impairment in new learning abilities, to a memory retraining group or a placebo control group. Both groups will undergo baseline, immediate and long-term follow-up assessment consisting of: (1) a traditional neuropsychological battery and (2) an assessment of global functioning examining the impact of the treatment on daily activities. This design will allow us to evaluate the efficacy of this particular memory retraining technique in an MS population through the assessment of cognitive function via a standard evaluation. In addition, we will be able to draw conclusions regarding the impact of this particular memory remediation program on everyday life from questionnaires completed by the participant and a significant other.

描述（由申请人提供）：NCMRR咨询委员会强调了“医疗康复干预措施有效性研究"的必要性，使用新的和精确的定量测量方法，包括功能和社会限制和残疾。“目前的提案通过一项双盲、安慰剂对照、随机临床试验来研究记忆再训练对多发性硬化症（MS）的疗效，从而解决了这一建议。高级认知处理（如新的学习和记忆）的障碍是MS患者最常见的缺陷之一，并且此类缺陷已被证明对日常生活的多个方面（包括职业和社会功能）产生显著的负面影响。尽管有这些发现，很少有研究试图治疗这些认知缺陷，以改善个人MS的日常功能。通过一个小型的随机临床试验，我们发现，个人MS与记录的记忆障碍显示出显着改善他们的记忆表现后，利用图像和上下文的治疗方案，以促进学习。当前提案将复制这一发现，并进一步评价（a）治疗对日常功能的影响，（B）治疗的长期疗效和（c）加强疗程在促进长期治疗效果方面的效用。我们将随机分配患有MS的个体，记录新学习能力的损害，到记忆再训练组或安慰剂对照组。两组均将接受基线、即刻和长期随访评估，包括：（1）传统神经心理成套测试和（2）检查治疗对日常活动影响的整体功能评估。该设计将允许我们通过经由标准评估的认知功能评估来评估这种特定记忆再训练技术在MS人群中的功效。此外，我们将能够从参与者和重要的其他人完成的问卷中得出关于这种特定记忆补救计划对日常生活的影响的结论。

项目成果

Cognitive impairment in multiple sclerosis.

• DOI: 10.1007/s11910-012-0294-3
• 发表时间: 2012-10
• 期刊: Current neurology and neuroscience reports
• 影响因子: 5.6
• 作者: Lovera J;Kovner B
• 通讯作者: Kovner B

Could behavioral therapies target specific deficits in multiple sclerosis patients?

行为疗法能否针对多发性硬化症患者的特定缺陷？

• DOI: 10.1586/ern.12.68
• 发表时间: 2012
• 期刊: Expert review of neurotherapeutics
• 影响因子: 4.3
• 作者: Chiaravalloti,NancyD

A pilot study of changes in functional brain activity during a working memory task after mSMT treatment: The MEMREHAB trial.

• DOI: 10.1016/j.msard.2016.03.012
• 发表时间: 2016-05
• 期刊: Multiple sclerosis and related disorders
• 影响因子: 4
• 作者: Huiskamp M;Dobryakova E;Wylie GD;DeLuca J;Chiaravalloti ND
• 通讯作者: Chiaravalloti ND

The relationship between executive functioning, processing speed, and white matter integrity in multiple sclerosis.

• DOI: 10.1080/13803395.2013.806649
• 发表时间: 2013
• 期刊: Journal of clinical and experimental neuropsychology
• 影响因子: 2.2
• 作者: Genova HM;DeLuca J;Chiaravalloti N;Wylie G
• 通讯作者: Wylie G

Does slowed processing speed account for executive deficits in multiple sclerosis? Evidence from neuropsychological performance and structural neuroimaging.

处理速度减慢是否是多发性硬化症执行缺陷的原因？

• DOI: 10.1037/a0037517
• 发表时间: 2014
• 期刊: Rehabilitation psychology
• 影响因子: 2.7
• 作者: Leavitt,VictoriaM;Wylie,Glenn;Krch,Denise;Chiaravalloti,Nancy;DeLuca,John;Sumowski,JamesF
• 通讯作者: Sumowski,JamesF