ANKYRIN-B SYNDROME

锚蛋白-B综合征

• 批准号: 7358282
• 负责人: VANN BENNETT
• 金额: $ 1.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358282
• 关键词: ANKYRIN; SYNDROME

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are characterizing mice heterozygous for a null mutation in ankyrin-B. These animals are viable, but have a reduced life span. We need to evaluate a number of tissues as well possible tumors in these mice. A very efficient way to look at the whole animal and preserve three-dimensional information would be to MRI scan a fixed animal that could subsequently be evaluated by conventional histology. We will specifically evaluate the following in 3-month and 12-month-old mice (control and heterozygotes): the size of the brain, kidney, thymus, and spleen; possible dilated cardiomyopathy; possible tumors/masses. It would be impossible to obtain this level of analysis from conventional histology alone.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们正在研究锚蛋白B无效突变的杂合子小鼠。这些动物是可行的，但寿命缩短。我们需要评估这些小鼠的一些组织以及可能的肿瘤。观察整个动物并保存三维信息的一种非常有效的方法是对固定的动物进行MRI扫描，随后可以通过常规组织学进行评估。我们将在3月龄和12月龄小鼠（对照和杂合子）中专门评价以下内容：脑、肾脏、胸腺和脾脏的大小;可能的扩张型心肌病;可能的肿瘤/肿块。仅从常规组织学中不可能获得这种水平的分析。