ROLE OF ION FLUXES DURING PATTERNING & EMBRYOGENESIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们正在探索离子通量在两个脊椎动物发育阶段的深刻作用：早期胚胎发生时左右（LR）轴的建立和模式，以及截肢附属物再生时皮肤、肌肉、骨骼和脊髓的再生。（见SPID 0104）这两个过程都是令人着迷的问题，对于指导生物医学方法的设计至关重要，在LR模式的情况下，纠正出生缺陷（如左心发育不全综合征、异位、脾功能不全、多脾、大血管转位、逆位等），这些缺陷加在一起影响8000多例出生，在再生的情况下，再造通过利用身体的潜在能力再造组织来替换患病或受损的组织

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring the profound roles of ion fluxes during two vertebrate developmental stages: the establishment and patterning of the left-right (LR) axis during early embryogenesis, and the regeneration of skin, muscle, skeleton, and spinal cord during regeneration of an amputated appendage. (See SPID 0104) Both of these processes are fascinating as questions, and critically important for guiding the design of biomedical approaches to, in the case of LR patterning, correct birth defects (such as Hypoplastic Left Heart Syndrome, heterotaxy, asplenia, polysplenia, transposition of the major blood vessels, situs inversus, etc.) which together affect more than 1 in 8000 births, and, in the case of regeneration, to replace diseased or damaged tissue by harnessing the body's latent ability to recreate tissue.