PYRUVATE DEHYDROGENASE COMPLEX

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。丙酮酸脱氢酶复合物催化丙酮酸氧化脱羧成乙酰辅酶A，在细胞呼吸过程中将糖酵解与克雷布循环连接起来。这种酶的缺陷通常是致命的。 PDC 具有二十面体二氢硫辛酰转乙酰酶 (E2p) 核心，其周围有 12 个拷贝的二氢硫辛酰胺脱氢酶 (E3)。 这些 E3 蛋白通过 12 个 E3 结合蛋白 (E3BP) 拷贝通过非共价蛋白质-蛋白质相互作用附着到 E2p 核心。 E2 核心还附着 30 个丙酮酸脱氢酶 (E1p) 亚基拷贝

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate into AceylCoA linking glycolysis to the Kreb Cycle during cellular respiration. Defects in this enzyme generally are fatal. PDC has an icosahedral dihydrolipoyl transacetylase (E2p) core which is surrounded by 12 copies of dihydrolipoamide dehydrogenase (E3). These E3 protiens are attached to the E2p core via 12 copies of E3-binding protein (E3BP) by non-covalent protein-protein interactions. Also attached to the E2 core are 30 copies of pyruvate dehydrogenase (E1p) subunits