PYRUVATE DEHYDROGENASE COMPLEX

丙酮酸脱氢酶复合物

• 批准号: 7357829
• 负责人: DAVID T CHUANG
• 金额: $ 1.51万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357829
• 关键词: PYRUVATE; DEHYDROGENASE; COMPLEX

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate into AceylCoA linking glycolysis to the Kreb Cycle during cellular respiration. Defects in this enzyme generally are fatal. PDC has an icosahedral dihydrolipoyl transacetylase (E2p) core which is surrounded by 12 copies of dihydrolipoamide dehydrogenase (E3). These E3 protiens are attached to the E2p core via 12 copies of E3-binding protein (E3BP) by non-covalent protein-protein interactions. Also attached to the E2 core are 30 copies of pyruvate dehydrogenase (E1p) subunits

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。丙酮酸脱氢酶复合物催化丙酮酸氧化脱羧为乙酰辅酶A，将糖酵解与细胞呼吸过程中的Kreb循环联系起来。这种酶的缺陷通常是致命的。PDC具有二十面体二氢硫辛酰转乙酰酶（E2 p）核心，其被12个拷贝的二氢硫辛酰胺脱氢酶（E3）包围。 这些E3蛋白通过非共价蛋白质-蛋白质相互作用经由12个拷贝的E3结合蛋白（E3 BP）连接到E2 p核心。E2核心上还连接着30个拷贝的丙酮酸脱氢酶（E1 p）亚基