PYRUVATE DEHYDROGENASE COMPLEX

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。丙酮酸脱氢酶复合物催化丙酮酸氧化脱羧成乙酰辅酶a，在细胞呼吸过程中将糖酵解与克雷布循环连接起来。这种酶的缺陷通常是致命的。PDC具有一个二十面体二氢脂酰基转乙酰化酶（E2p）核，核周围有12个拷贝的二氢脂酰胺脱氢酶（E3）。这些E3蛋白通过非共价蛋白-蛋白相互作用通过12个拷贝的E3结合蛋白（E3BP）附着在E2p核心上。E2核心上还附着着30个丙酮酸脱氢酶（E1p）亚基

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pyruvate dehydrogenase complex catalyzes the oxidative decarboxylation of pyruvate into AceylCoA linking glycolysis to the Kreb Cycle during cellular respiration. Defects in this enzyme generally are fatal. PDC has an icosahedral dihydrolipoyl transacetylase (E2p) core which is surrounded by 12 copies of dihydrolipoamide dehydrogenase (E3). These E3 protiens are attached to the E2p core via 12 copies of E3-binding protein (E3BP) by non-covalent protein-protein interactions. Also attached to the E2 core are 30 copies of pyruvate dehydrogenase (E1p) subunits