BACTERIAL CHAPERONIN MACHINES
细菌伴侣机器
基本信息
- 批准号:7721141
- 负责人:
- 金额:$ 6.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-12-01 至 2008-11-30
- 项目状态:已结题
- 来源:
- 关键词:BindingComplexComputer Retrieval of Information on Scientific Projects DatabaseFundingGoalsGrantHomologous GeneInstitutionMediatingMitochondriaModelingMolecular ChaperonesMolecular StructureProteinsResearchResearch PersonnelResolutionResourcesSourceUnited States National Institutes of Healthchaperonininterestmutantpolypeptidepreventprotein foldingreconstructionsizesynthetic peptidethree dimensional structure
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Chaperonins function by interacting with nascent or unfolded polypeptides to prevent misfolding, which otherwise leads to aggregation. Bacterial chaperonins GroEL/GroES are homologues of mitochondrial Hsp60/Hsp10, respectively. GroEL is a 14-meric double-ring complex of 800 kDa in size, whereas its co-chaperonin GroES is a 70-kDa 7-meric single-ring complex. The mechanism by which molecular chaperones promote proper folding is of intense interest. However, most studies have used small proteins or synthetic peptides as model substrates. Limited information is available as to how these chaperones mediate folding and/or assembly of hetero-oligomeric proteins or macromolecular structures. To understand the mechanism underlying chaperonin-assisted protein folding and assembly, we plan to dp the following cryo-EM studies.
Specific Aims:
1. To continue using the GroEL double-ring complex as a model for cryo-EM reconstruction with the goal of attaining 4-¿ resolution.
2. To determine three-dimensional structures of single ring mutant of GroEL bound with substrate.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID T CHUANG其他文献
DAVID T CHUANG的其他文献
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{{ truncateString('DAVID T CHUANG', 18)}}的其他基金
Structure and Function of Mitochondrial Protein Kinases
线粒体蛋白激酶的结构和功能
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- 资助金额:
$ 6.49万 - 项目类别:
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